Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.08.026
Abstract: Regulation of photoreceptor phosphodiesterase (PDE6) activity is responsible for the speed, sensitivity, and recovery of the photoresponse during visual signaling in vertebrate photoreceptor cells. It is hypothesized that physiological differences in the light responsiveness of… read more here.
Keywords: phosphodiesterase; allosteric communication; gaf domains; cone ... See more keywords
New focus on regulation of the rod photoreceptor phosphodiesterase.
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DOI: 10.1016/j.sbi.2021.03.016
Abstract: Rod photoreceptor phosphodiesterase (PDE6) is the key catalytic enzyme of visual phototransduction. PDE6 is the only member of the phosphodiesterase family that consists of a heterodimeric catalytic core composed of PDE6α and PDE6β subunits and… read more here.
Keywords: pde6 pde6; rod photoreceptor; photoreceptor phosphodiesterase; pde6 ... See more keywords
It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods
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DOI: 10.1098/rsob.180075
Abstract: Among cyclic nucleotide phosphodiesterases (PDEs), PDE6 is unique in serving as an effector enzyme in G protein-coupled signal transduction. In retinal rods and cones, PDE6 is membrane-bound and activated to hydrolyse its substrate, cGMP, by… read more here.
Keywords: two transducins; takes two; membrane bound; retinal rods ... See more keywords