Channeling of cAMP in PDE-PKA Complexes Promotes Signal Adaptation.
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DOI: 10.1016/j.bpj.2017.04.045
Abstract: Spatiotemporal control of the cAMP signaling pathway is governed by both hormonal stimulation of cAMP generation by adenylyl cyclases (activation phase) and cAMP hydrolysis by phosphodiesterases (PDEs) (termination phase). The termination phase is initiated by… read more here.
Keywords: camp; pde8 complex; pde; hydrolysis ... See more keywords