Hemodynamic, Hormonal, and Renal Actions of Phosphodiesterase-9 Inhibition in Experimental Heart Failure.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.05.067
Abstract: BACKGROUND Phosphodiesterase-9 (PDE9) reduces natriuretic peptide (NP) signaling and may be involved in the pathophysiology of heart failure (HF). OBJECTIVES This study investigated for the first time the integrated hemodynamic, endocrine, and renal effects of… read more here.
Keywords: normal 001; phosphodiesterase inhibition; inhibition; heart failure ... See more keywords
Multitarget Approach for the Treatment of Alzheimer`s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) covering diverse selectivity profiles.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00303
Abstract: Here, we present a series of dual-target PDE9/HDAC inhibitors devised as pharmacological tool compounds for assessing the implications of these two targets in Alzheimer's Disease (AD). These novel inhibitors were designed taking into account the… read more here.
Keywords: alzheimer disease; histone; selectivity profiles; pde9 ... See more keywords
Computational Study on Selective PDE9 Inhibitors on PDE9-Mg/Mg, PDE9-Zn/Mg, and PDE9-Zn/Zn Systems
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11050709
Abstract: PDE9 inhibitors have been studied to validate their potential to treat diabetes, neurodegenerative disorders, cardiovascular diseases, and erectile dysfunction. In this report, we have selected highly potent previously reported selective PDE9 inhibitors BAY73-6691R, BAY73-6691S, 28r,… read more here.
Keywords: pde9 pde9; computational study; selective pde9; study selective ... See more keywords