HSPGs glypican‐1 and glypican‐4 are human neuronal proteins characteristic of different neural phenotypes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24666
Abstract: Generating neurons from human stem cells has potential for brain damage therapy and neurogenesis modeling, but current efficacy is limited by culture heterogeneity and the lack of markers. We have previously reported the heparan sulfate… read more here.
Keywords: neural differentiation; gpc1 gpc4; differentiation; hspgs glypican ... See more keywords
Combined VEGF and PDGF inhibition for neovascular AMD: anti-angiogenic properties of axitinib on human endothelial cells and pericytes in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-017-3595-z
Abstract: PurposeDrugs currently approved for neovascular age-related macular degeneration (nAMD) offer anti-VEGF monotherapy only. Platelet-derived growth factor (PDGF) signaling is pivotal to pericyte-induced stabilization of choroidal neovascularizations (CNV), and causes partial anti-VEGF resistance. No combination therapy… read more here.
Keywords: angiogenic properties; vegf pdgf; endothelial cells; properties axitinib ... See more keywords
Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity
Sign Up to like & getrecommendations! Published in 2020 at "Angiogenesis"
DOI: 10.1007/s10456-020-09738-6
Abstract: Platelet-derived growth factor-B (PDGF-B) is a main factor to promote adipose tissue angiogenesis, which is responsible for the tissue expansion in obesity. In this process, PDGF-B induces the dissociation of pericytes from blood vessels; however,… read more here.
Keywords: tissue; adipose tissue; obesity; factor ... See more keywords
The PDGF pathway in breast cancer is linked to tumour aggressiveness, triple-negative subtype and early recurrence
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4664-7
Abstract: PurposeThe platelet-derived growth factor (PDGF) signalling pathway is often dysregulated in cancer and PDGF-receptor expression has been linked to unfavourable prognostic factors in breast cancer (e.g. ER negativity, high Ki67 and high grade). This study… read more here.
Keywords: recurrence; breast cancer; expression; cancer ... See more keywords
Effect of Korean Magnolia obovata Extract on Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cells
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-019-3171-y
Abstract: To investigate the effects of Korean Magnolia obovata crude extract (KME) on plateletderived growth factor (PDGF)-BB-induced proliferation and migration of vascular smooth muscle cells (VSMCs). KME composition was analyzed by high-performance liquid chromatography (HPLC). VSMCs… read more here.
Keywords: vascular smooth; proliferation; growth factor; magnolia obovata ... See more keywords
Expression and purification of functional PDGF receptor beta.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.091
Abstract: Platelet Derived Growth Factor receptors (PDGFRs), members of receptor tyrosine kinase superfamily, play essential roles in early hematopoiesis, angiogenesis and organ development. Dysregulation of PDGF receptor signaling under pathological conditions associates with cancers, vascular diseases,… read more here.
Keywords: pdgf receptor; purification functional; expression purification; pdgf ... See more keywords
The endocannabinoid 2‐arachidonoylglycerol regulates oligodendrocyte progenitor cell migration
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.09.006
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT While the endocannabinoid 2‐arachidonoylglycerol (2‐AG) is thought to enhance the proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) in vitro, less is known about how endogenous 2‐AG may… read more here.
Keywords: migration; oligodendrocyte progenitor; cb1 cb2; endocannabinoid arachidonoylglycerol ... See more keywords
In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.09.028
Abstract: Recapitulating the typical features of extracellular matrix (ECM) in engineered biomaterials is crucial for preparing a suitable niche to activate endogenous tissue repair. Here, we report the design and evaluation of an ECM-mimetic scaffold that… read more here.
Keywords: ecm mimetic; wound healing; endogenous pdgf; tissue ... See more keywords
Elastic and surgeon friendly electrospun tubes delivering PDGF-BB positively impact tendon rupture healing in a rabbit Achilles tendon model.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119722
Abstract: A major problem after tendon laceration is the low mechanical strength of the repaired tissue. One viable strategy for improving the functional and biomechanical properties of ruptured and repaired tendons is the delivery of growth… read more here.
Keywords: healing rabbit; surgeon friendly; achilles tendon; electrospun tubes ... See more keywords
Human adipose-derived stem cell spheroids incorporating platelet-derived growth factor (PDGF) and bio-minerals for vascularized bone tissue engineering.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120192
Abstract: Stem cells with mineralized materials have been used for bone regeneration; however, engineering the complex vascularized structure of the natural bone remains a challenge. Here, we developed platelet-derived growth factor (PDGF) and bio-mineral coated fibers… read more here.
Keywords: pdgf bio; vascularized bone; bone; stem ... See more keywords
Long-term local PDGF delivery using porous microspheres modified with heparin for tendon healing of rotator cuff tendinitis in a rabbit model.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.01.017
Abstract: In this study, we prepared the platelet-derived growth factor-containing porous microspheres modified with heparin (PDGF/Hep-PMSs) and investigated their anti-inflammatory and tendon healing effects on rotator cuff (RC) tendinitis rabbit model. PDGF/Hep-PMSs suppressed the mRNA levels… read more here.
Keywords: pdgf hep; long term; tendon; tendon healing ... See more keywords