Regulation of autophagy by controlling Erk1/2 and mTOR for platelet-derived growth factor-BB-mediated vascular smooth muscle cell phenotype shift.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118978
Abstract: AIMS Vascular smooth muscle cell (VSMC) phenotype shift is involved in the pathophysiology of vascular injury or platelet-derived growth factor (PDGF)-induced abnormal proliferation and migration of VSMCs. We aimed to investigate the underlying mechanism involved… read more here.
Keywords: pdgf induced; cell; smooth muscle; phenotype shift ... See more keywords
DLEU2 modulates proliferation, migration and invasion of platelet-derived growth factor-BB (PDGF-BB)-induced vascular smooth muscle cells (VSMCs) via miR-212-5p/YWHAZ axis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2079175
Abstract: ABSTRACT DLEU2 has been proved to act as an oncogene in a variety of cancers, but its role in cardiovascular diseases is dearth of research. Thus, this study mainly discussed the effect and possible mechanism… read more here.
Keywords: 212 ywhaz; dleu2; mir 212; smooth muscle ... See more keywords
SphK1/S1P Mediates PDGF-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation via miR-21/BMPRII/Id1 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000495243
Abstract: Background/Aims: The underlying molecular mechanisms involved in sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate (S1P) mediation of platelet-derived growth factor (PDGF)-induced pulmonary arterial smooth muscle cell (PASMC) proliferation are still unclear, and the present study aims to… read more here.
Keywords: pdgf induced; expression; bmprii id1; proliferation ... See more keywords
TRIM33 Modulates Inflammation and Airway Remodeling of PDGF-BB-Induced Airway Smooth-Muscle Cells by the Wnt/β-Catenin Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000524574
Abstract: Asthma is a chronic airway disease involving airway inflammation and remodeling. Studies showed that tripartite motif-containing protein 33 (TRIM33) regulated natural immunity, inflammation, and pulmonary fibrosis. However, the role and regulatory mechanism of TRIM33 in… read more here.
Keywords: trim33; wnt catenin; airway remodeling; inflammation airway ... See more keywords
Abstract 1157: Inhibition Of P90rsk Ameliorates Pdgf-bb-induced Vascular Smooth Muscle Cell Phenotypic Change And Neointimal Hyperplasia
Sign Up to like & getrecommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvb.44.suppl_1.1157
Abstract: Platelet-derived growth factor type BB (PDGF-BB) has been reported to induce vascular smooth muscle cell (VSMC) proliferation and migration, which are major events that are highly linked to vascular diseases such as atherosclerosis and restenosis.… read more here.
Keywords: p90rsk; pdgf induced; inhibition; cell ... See more keywords
M6A Methylase METTL3-mediated downregulation of TEP1 mRNA stability attenuates PDGF-BB-induced HASMC remodeling and inflammation via macrophage polarization
Sign Up to like & getrecommendations! Published in 2025 at "BMC Pediatrics"
DOI: 10.1186/s12887-025-05783-6
Abstract: Childhood asthma is a chronic inflammatory disease of the respiratory tract characterized by the contraction of smooth muscle, remodeling of the airway wall, bronchial inflammation, and obstruction, which is associated with increased airway smooth muscle… read more here.
Keywords: mettl3; tep1; macrophage polarization; pdgf induced ... See more keywords
S100A8 inhibits PDGF-induced proliferation of airway smooth muscle cells dependent on the receptor for advanced glycation end-products
Sign Up to like & getrecommendations! Published in 2017 at "Biological Research"
DOI: 10.1186/s40659-017-0128-5
Abstract: BackgroundAirway remodeling is a key feature of asthma, characterized by increased proliferation of airway smooth muscle cells (ASMCs). S100A8 is a calcium-binding protein with a potential to regulate cell proliferation. Here, the effect of exogenous… read more here.
Keywords: pdgf induced; proliferation airway; s100a8; proliferation ... See more keywords
Evening Primrose Extracts Inhibit PDGF-BB-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Regulating Cell-Cycle-Related Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44050131
Abstract: The proliferation and migration of vascular smooth muscle cells (VSMCs) are important factors in the occurrence of cardiovascular diseases, such as blood flow abnormalities, stroke and atherosclerosis. Evening primrose, known as Oenothera biennis, is a… read more here.
Keywords: cell; proliferation migration; proliferation; cell cycle ... See more keywords
β-Tocotrienol Decreases PDGF-BB-Induced Proliferation and Migration of Human Airway Smooth Muscle Cells by Inhibiting RhoA and Reducing ROS Production
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceuticals"
DOI: 10.3390/ph17060712
Abstract: Background: Tocotrienols exhibit antioxidant and anti-inflammatory activities. RhoA, a small GTPase protein, plays a crucial role in regulating contractility in airway smooth muscle (ASM). Previous studies have demonstrated that γ-tocotrienols reduce ASM proliferation and migration… read more here.
Keywords: migration; proliferation migration; pdgf induced; human asm ... See more keywords
Morin inhibits PDGF-induced proliferation, migration, and invasion of vascular smooth muscle cells via modulating p27KIP1, AKT, and MMP-9 activities.
Sign Up to like & getrecommendations! Published in 2018 at "General physiology and biophysics"
DOI: 10.4149/gpb_2018028
Abstract: Hyper-proliferation and migration of vascular smooth muscle cells (VSMCs) are closely associated with atherosclerosis. Recently, the flavonol morin has been reported to exhibit potent anti-oxidant and anti-inflammatory activities. Therefore, we investigated molecular mechanisms of morin… read more here.
Keywords: pdgf induced; proliferation migration; vascular smooth; proliferation ... See more keywords