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   Articles with "pdgf pdgfr" as a keyword



The role of PDGF-B/PDGFR-BETA axis in the normal development and carcinogenesis of the breast.

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recommendations! Published in 2018 at "Critical reviews in oncology/hematology"

DOI: 10.1016/j.critrevonc.2018.08.002

Abstract: PDGFs/PDGFRs axis is documented as an important tumor-promoting agent and potential therapeutic target for several human carcinomas, including breast cancer. However, little is known about the role played by the PDGF family members in the… read more here.

Keywords: beta axis; breast; pdgfr beta; role ... See more keywords
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Endothelial Cells Promote Migration of Mesenchymal Stem Cells via PDGF-BB/PDGFRβ-Src-Akt in the Context of Inflammatory Microenvironment upon Bone Defect

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recommendations! Published in 2022 at "Stem Cells International"

DOI: 10.1155/2022/2401693

Abstract: Homing of mesenchymal stem cells (MSCs) to the defect site is indispensable for bone repair. Local endothelial cells (ECs) can recruit MSCs; however, the mechanism remains unclear, especially in the context of the inflammatory microenvironment.… read more here.

Keywords: pdgf; inflammatory microenvironment; pdgf pdgfr; src akt ... See more keywords
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PDGF/PDGFR: A Possible Molecular Target in Scleroderma Fibrosis

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23073904

Abstract: Systemic sclerosis (SSc) is a clinically heterogeneous disorder of the connective tissue characterized by vascular alterations, immune/inflammatory manifestations, and organ fibrosis. SSc pathogenesis is complex and still poorly understood. Therefore, effective therapies are lacking and… read more here.

Keywords: pdgfr possible; possible molecular; fibrosis; pdgf pdgfr ... See more keywords
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PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a Temporal Manner

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recommendations! Published in 2023 at "Research"

DOI: 10.34133/research.0086

Abstract: Platelet-derived growth factor-BB (PDGF-BB)/platelet-derived growth factor receptor-β (PDGFR-β) pathway is conventionally considered as an important pathway to promote osteogenesis; however, recent study suggested its role during osteogenesis to be controversial. Regarding the differential functions of… read more here.

Keywords: pdgfr pathway; pdgf pdgfr; osteogenesis; pdgfr ... See more keywords