Expression and purification of functional PDGF receptor beta.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.091
Abstract: Platelet Derived Growth Factor receptors (PDGFRs), members of receptor tyrosine kinase superfamily, play essential roles in early hematopoiesis, angiogenesis and organ development. Dysregulation of PDGF receptor signaling under pathological conditions associates with cancers, vascular diseases,… read more here.
Keywords: pdgf receptor; purification functional; expression purification; pdgf ... See more keywords
Amyloid-β Inhibits PDGFβ Receptor Activation and Prevents PDGF-BBInduced Neuroprotection.
Sign Up to like & getrecommendations! Published in 2018 at "Current Alzheimer research"
DOI: 10.2174/1567205015666180110110321
Abstract: BACKGROUND PDGFβ receptors and their ligand, PDGF-BB, are upregulated in vivo after neuronal insults such as ischemia. When applied exogenously, PDGF-BB is neuroprotective against excitotoxicity and HIV proteins. OBJECTIVE Given this growth factor's neuroprotective ability,… read more here.
Keywords: receptor activation; amyloid; ability; receptor ... See more keywords