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Total flavonoids of Rhizoma Drynariae enhances CD31hiEmcnhi vessel formation and subsequent bone regeneration in rat models of distraction osteogenesis by activating PDGF-BB/VEGF/RUNX2/OSX signaling axis

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Published in 2022 at "International Journal of Molecular Medicine"

DOI: 10.3892/ijmm.2022.5167

Abstract: Total flavonoids of Rhizoma Drynariae (TFRD), extracted from the kidney-tonifying Traditional Chinese medicine Rhizoma Drynariae, can be effective in treating osteoporosis, bone fractures and defects. However, the pharmacological effects of TFRD on the specific vessel… read more here.

Keywords: bone; vessel formation; pdgf vegf; formation ... See more keywords