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   Articles with "pdgfb" as a keyword



Familial Brain Calcifications With Leukoencephalopathy

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recommendations! Published in 2022 at "Neurology: Genetics"

DOI: 10.1212/nxg.0000000000200001

Abstract: Objective To describe a family with primary familial brain calcifications (PFBCs) and leukoencephalopathy associated with a novel variant in PDGFB. Methods We present 3 generations of a family with PFBC associated with a previously unreported… read more here.

Keywords: calcifications leukoencephalopathy; basal ganglia; familial brain; brain calcifications ... See more keywords

Platelet-derived growth factor subunit B overexpression promotes lung cancer tumor growth and metastasis: The role of glucose metabolism

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recommendations! Published in 2025 at "CytoJournal"

DOI: 10.25259/cytojournal_190_2024

Abstract: Objective Lung cancer represents a formidable global health challenge due to its substantial prevalence and mortality rates. Metabolic reprogramming, especially the transition to aerobic glycolysis, plays a pivotal role in the progression of lung cancer… read more here.

Keywords: cancer; pdgfb; lung cancer; tumor ... See more keywords
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Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgfβ Signaling in the Tumor Microenvironment

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14081947

Abstract: Simple Summary The aim of this study was to investigate the relative contribution of PDGFB derived specifically from platelets to the remodeling of the extracellular matrix (ECM) in tumors. Platelets are a major source of… read more here.

Keywords: pdgfb; tumor microenvironment; tumor; platelet ... See more keywords

Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24076447

Abstract: Clear cell renal cell carcinoma (ccRCC) is a hypervascular tumor that is characterized by bi-allelic inactivation of the VHL tumor suppressor gene and mTOR signalling pathway hyperactivation. The pro-angiogenic factor PDGFB, a transcriptional target of… read more here.

Keywords: cell; ccrcc; ccrcc cells; mtorc1 signalling ... See more keywords

KLF7 promotes colon adenocarcinoma progression through the PDGFB signaling pathway

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recommendations! Published in 2024 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.86385

Abstract: Colon adenocarcinoma (COAD) is the most common malignancy of the digestive tract, which is characterized by a dismal prognosis. No effective treatment has been established presently, thus there is an urgent need to understand the… read more here.

Keywords: klf7 promotes; pdgfb; progression; colon adenocarcinoma ... See more keywords