Familial Brain Calcifications With Leukoencephalopathy
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DOI: 10.1212/nxg.0000000000200001
Abstract: Objective To describe a family with primary familial brain calcifications (PFBCs) and leukoencephalopathy associated with a novel variant in PDGFB. Methods We present 3 generations of a family with PFBC associated with a previously unreported… read more here.
Keywords: calcifications leukoencephalopathy; basal ganglia; familial brain; brain calcifications ... See more keywords
Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgfβ Signaling in the Tumor Microenvironment
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DOI: 10.3390/cancers14081947
Abstract: Simple Summary The aim of this study was to investigate the relative contribution of PDGFB derived specifically from platelets to the remodeling of the extracellular matrix (ECM) in tumors. Platelets are a major source of… read more here.
Keywords: pdgfb; tumor microenvironment; tumor; platelet ... See more keywords
Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma
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DOI: 10.3390/ijms24076447
Abstract: Clear cell renal cell carcinoma (ccRCC) is a hypervascular tumor that is characterized by bi-allelic inactivation of the VHL tumor suppressor gene and mTOR signalling pathway hyperactivation. The pro-angiogenic factor PDGFB, a transcriptional target of… read more here.
Keywords: cell; ccrcc; ccrcc cells; mtorc1 signalling ... See more keywords