Leptin is a physiological regulator of skeletal muscle angiogenesis and is locally produced by PDGFRα and PDGFRβ expressing perivascular cells
Sign Up to like & getrecommendations! Published in 2018 at "Angiogenesis"
DOI: 10.1007/s10456-018-9641-6
Abstract: Skeletal muscle capillarity is characteristically reduced in mature leptin receptor-deficient (Leprdb) mice, which has been attributed to the capillary loss that occurs secondary to metabolic dysfunction. Despite wide recognition of leptin as a pro-angiogenic molecule,… read more here.
Keywords: skeletal muscle; muscle angiogenesis; muscle; leptin physiological ... See more keywords
The PDGF pathway in breast cancer is linked to tumour aggressiveness, triple-negative subtype and early recurrence
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4664-7
Abstract: PurposeThe platelet-derived growth factor (PDGF) signalling pathway is often dysregulated in cancer and PDGF-receptor expression has been linked to unfavourable prognostic factors in breast cancer (e.g. ER negativity, high Ki67 and high grade). This study… read more here.
Keywords: recurrence; breast cancer; expression; cancer ... See more keywords
68Ga-PSMA-11 PET/CT Parameter Correlates with Pathological VEGFR-2/PDGFR-β Expression in Renal Cell Carcinoma Patients
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-022-01725-1
Abstract: Response prediction is necessary for renal cell carcinoma (RCC) tumors. We aim to evaluate parameters derived from 68 Ga-PSMA-11 PET/CT images for prediction of pathological VEGFR-2/PDGFR-β expression of primary RCC tumors. Forty-eight RCC patients were… read more here.
Keywords: expression; vegfr pdgfr; pdgfr expression; psma pet ... See more keywords
Ultrastructural and Molecular Characterization of Platelet-derived growth factor Beta-Positive Leptomeningeal Cells in the Adult Rat Brain
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01793-5
Abstract: The leptomeninges, referring to the arachnoid and pia mater and their projections into the perivascular compartments in the central nervous system, actively participate in diverse biological processes including fluid homeostasis, immune cell infiltrations, and neurogenesis,… read more here.
Keywords: pdgfr cells; factor beta; growth factor; pdgfr ... See more keywords
A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.04.036
Abstract: Background Platelet Derived Growth Factor Receptor beta (PDGFRβ) has been associated to hepatic stellate cell activation and has been the target of multiple therapeutic studies. However, little is known concerning its use as a diagnostic… read more here.
Keywords: liver disease; pdgfr; fibrosis; liver fibrosis ... See more keywords
Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121623
Abstract: Impairment of oligodendrocyte progenitor cell (OPC) differentiation into oligodendrocytes and chronic inflammation are key determinants of poor remyelination observed in diseases such as multiple sclerosis. For many pro-myelinating molecules, the therapeutic potential is hindered by… read more here.
Keywords: pdgfr; oligodendrocyte progenitor; pdgfr antibody; anti pdgfr ... See more keywords
Different subpopulations of kidney interstitial cells produce erythropoietin and factors supporting tissue oxygenation in response to hypoxia in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.04.040
Abstract: Genetic induction of hypoxia signaling by deletion of the von Hippel-Lindau (Vhl) protein in mesenchymal PDGFR-β+ cells leads to abundant HIF-2 dependent erythropoietin (EPO) expression in the cortex and outer medulla of the kidney. This… read more here.
Keywords: response; response hypoxia; kidney interstitial; hypoxia ... See more keywords
PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors
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DOI: 10.1016/j.stemcr.2016.12.010
Abstract: Summary In early mouse pre-implantation development, primitive endoderm (PrE) precursors are platelet-derived growth factor receptor alpha (PDGFRα) positive. Here, we demonstrated that cultured mouse embryonic stem cells (mESCs) express PDGFRα heterogeneously, fluctuating between a PDGFRα+… read more here.
Keywords: cell; pre implantation; primitive endoderm; pre ... See more keywords
Discovery of Potent and Orally Bioavailable Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for the Treatment of Osteosarcoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01732
Abstract: Platelet-derived growth factor receptors (PDGFRs) are now considered promising targets for the treatment of osteosarcoma. Herein, the design, synthesis, and structure-activity relationships (SAR) of novel pyrimidine-2,4-diamine derivatives that selectively inhibit PDGFRα/β kinases have been studied.… read more here.
Keywords: treatment osteosarcoma; pdgfr; growth factor; derived growth ... See more keywords
PDGFR-induced autocrine SDF-1 signaling in cancer cells promotes metastasis in advanced skin carcinoma
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DOI: 10.1038/s41388-019-0773-y
Abstract: Advanced and undifferentiated skin squamous cell carcinomas (SCCs) exhibit aggressive growth and enhanced metastasis capability, which is associated in mice with an expansion of the cancer stem-like cell (CSC) population and with changes in the… read more here.
Keywords: metastasis; autocrine sdf; metastasis advanced; pdgfr ... See more keywords
De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03196-x
Abstract: Pathologic expansion of white adipose tissue (WAT) in obesity is characterized by adipocyte hypertrophy, inflammation, and fibrosis; however, factors triggering this maladaptive remodeling are largely unknown. Here, we test the hypothesis that the potential to… read more here.
Keywords: expansion; pdgfr preadipocytes; visceral wat; obesity ... See more keywords