PDGFRα monoclonal antibody: Assessment of toxicity in juvenile mice administered a murine surrogate antibody of olaratumab
Sign Up to like & getrecommendations! Published in 2023 at "Birth Defects Research"
DOI: 10.1002/bdr2.2169
Abstract: Olaratumab (Lartruvo™) is a recombinant human IgG1 monoclonal antibody that specifically binds PDGFRα. In order to support use of Lartruvo in pediatric patients, a definitive juvenile animal study in neonatal mice was conducted with a… read more here.
Keywords: pdgfr monoclonal; monoclonal antibody; antibody assessment; mice ... See more keywords
A phase II study of a human anti-PDGFRα monoclonal antibody (olaratumab, IMC-3G3) in previously treated patients with metastatic gastrointestinal stromal tumors
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DOI: 10.1093/annonc/mdw659
Abstract: Background This study evaluated tumor response to olaratumab (an anti-PDGFRα monoclonal antibody) in previously treated patients with metastatic gastrointestinal stromal tumor (GIST) with or without PDGFRα mutations (cohorts 1 and 2, respectively). Patients and methods… read more here.
Keywords: patients cohort; cohort; anti pdgfr; pdgfr monoclonal ... See more keywords