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   Articles with "pdgfra" as a keyword



18F-Fluorodeoxyglucose Uptake in PDGFRA-Mutant Gastrointestinal Stromal Tumors

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recommendations! Published in 2025 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2024.56058

Abstract: Key Points Question What is the clinical role of positron emission tomography (PET) with 18F-fluorodeoxyglucose ([18F]FDG) in platelet-derived growth factor receptor α (PDGFRA)–mutant gastrointestinal stromal tumor (GIST), especially in the D842V-mutant subgroup? Findings In this… read more here.

Keywords: mutant gastrointestinal; pdgfra mutant; 18f fluorodeoxyglucose; 18f fdg ... See more keywords

Phosflow assessment of PDGFRA phosphorylation state: A guide for tyrosine kinase inhibitor targeted therapy in hypereosinophilia patients

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recommendations! Published in 2021 at "Cytometry Part A"

DOI: 10.1002/cyto.a.24302

Abstract: Clonal eosinophilia is a hematologic disorder caused by translocation in growth factor receptor (GFR) genes. Despite the identified molecular mechanisms underlying clonal hypereosinophilia, the distinction between clonal and reactive eosinophilia has remained challenging due to… read more here.

Keywords: state; pdgfra; hypereosinophilia patients; pdgfra phosphorylation ... See more keywords

H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.

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recommendations! Published in 2017 at "Cancer cell"

DOI: 10.1016/j.ccell.2017.09.014

Abstract: Gain-of-function mutations in histone 3 (H3) variants are found in a substantial proportion of pediatric high-grade gliomas (pHGG), often in association with TP53 loss and platelet-derived growth factor receptor alpha (PDGFRA) amplification. Here, we describe… read more here.

Keywords: pdgfra; high grade; gain; trp53 loss ... See more keywords
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PDGFRA Antibody for Soft Tissue Sarcoma

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recommendations! Published in 2017 at "Cell"

DOI: 10.1016/j.cell.2017.01.028

Abstract: Lartruvo (olaratumab) is a monoclonal antibody against the extracellular domain of PDGFRA. Olaratumab blocks ligand binding and thereby inhibits activation of PDGFRA kinase activity. Pre-clinically, this antibody inhibited PDGFRA-dependent tumor growth. In a randomized Phase… read more here.

Keywords: tissue sarcoma; soft tissue; pdgfra; antibody ... See more keywords

Association of MTOR and PDGFRA gene polymorphisms with different degrees of myopia severity.

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recommendations! Published in 2022 at "Experimental eye research"

DOI: 10.1016/j.exer.2022.108962

Abstract: This study aims to investigate the associations of SNPs in the mammalian target of rapamycin (MTOR) and the platelet derived growth factor receptor alpha (PDGFRA) genes with different degrees of myopia severity in Han and… read more here.

Keywords: pdgfra; degrees myopia; myopia severity; mtor ... See more keywords

Pdgfra regulates multipotent cell differentiation towards chondrocytes via inhibiting Wnt9a/beta-catenin pathway during chondrocranial cartilage development.

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recommendations! Published in 2020 at "Developmental biology"

DOI: 10.1016/j.ydbio.2020.08.004

Abstract: The mammalian skull is composed of the calvarial bones and cartilages. Malformation of craniofacial cartilage has been identified in multiple human syndromes. However, the mechanisms of their development remain largely unknown. In the present study,… read more here.

Keywords: pdgfra; chondrocranial cartilage; differentiation; cartilage development ... See more keywords

First-Generation Radiolabeled Cyclic Peptides for Molecular Imaging of Platelet-Derived Growth Factor Receptor α.

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recommendations! Published in 2024 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.4c00549

Abstract: Occult nodal spread and metastatic disease require longstanding imaging and biochemical assessments for thyroid cancer, a disease that has a propensity for diffuse, small-volume disease. We have developed a 64Cu-labeled platelet-derived growth factor receptor α… read more here.

Keywords: thyroid cancer; cell; peptide; pdgfra ... See more keywords

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-023-44376-8

Abstract: Avapritinib is the only potent and selective inhibitor approved for the treatment of D842V-mutant gastrointestinal stromal tumors (GIST), the most common primary mutation of the platelet-derived growth factor receptor α (PDGFRA). The approval was based… read more here.

Keywords: sar studies; avapritinib based; pocket; pdgfra ... See more keywords

Autophagy in PDGFRA+ mesenchymal cells is required for intestinal homeostasis and mammalian survival

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2090694

Abstract: ABSTRACT Macroautophagy/autophagy defects are a risk factor for inflamatory bowel disease (IBD), but the mechanism remains unclear. We previously demonstrated that conditional whole-body deletion of the essential Atg7 (autophagy related 7) gene in adult mice… read more here.

Keywords: deletion; loss; mesenchymal cells; autophagy ... See more keywords

A Novel USP25::PDGFRA Gene Fusion in a 78 Year Old Patient with a Myeloid Neoplasm.

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recommendations! Published in 2022 at "Laboratory medicine"

DOI: 10.1093/labmed/lmac010

Abstract: The World Health Organization category of myeloid/lymphoid neoplasms with eosinophilia and PDGFRA rearrangements is composed of a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, acute myeloid leukemia, myeloid sarcoma, or lymphoblastic… read more here.

Keywords: myeloid neoplasm; patient myeloid; novel usp25; myeloid ... See more keywords

CSIG-06. PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA AS AN ONCOGENIC DRIVER IN GLIOBLASTOMA

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recommendations! Published in 2020 at "Neuro-oncology"

DOI: 10.1093/neuonc/noaa215.118

Abstract: Activated platelet derived growth factor receptor alpha (PDGFRα) is essential for the maintenance of oligodendrocyte progenitors. Differential signaling results from phosphorylation of specific tyrosine residues in the kinase insert (KI) domain present in most RTKs… read more here.

Keywords: pdgfra; ecdna; growth factor; activation ... See more keywords