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   Articles with "pdgfra" as a keyword



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Phosflow assessment of PDGFRA phosphorylation state: A guide for tyrosine kinase inhibitor targeted therapy in hypereosinophilia patients

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recommendations! Published in 2021 at "Cytometry Part A"

DOI: 10.1002/cyto.a.24302

Abstract: Clonal eosinophilia is a hematologic disorder caused by translocation in growth factor receptor (GFR) genes. Despite the identified molecular mechanisms underlying clonal hypereosinophilia, the distinction between clonal and reactive eosinophilia has remained challenging due to… read more here.

Keywords: state; pdgfra; hypereosinophilia patients; pdgfra phosphorylation ... See more keywords
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H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.

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recommendations! Published in 2017 at "Cancer cell"

DOI: 10.1016/j.ccell.2017.09.014

Abstract: Gain-of-function mutations in histone 3 (H3) variants are found in a substantial proportion of pediatric high-grade gliomas (pHGG), often in association with TP53 loss and platelet-derived growth factor receptor alpha (PDGFRA) amplification. Here, we describe… read more here.

Keywords: pdgfra; high grade; gain; trp53 loss ... See more keywords
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PDGFRA Antibody for Soft Tissue Sarcoma

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recommendations! Published in 2017 at "Cell"

DOI: 10.1016/j.cell.2017.01.028

Abstract: Lartruvo (olaratumab) is a monoclonal antibody against the extracellular domain of PDGFRA. Olaratumab blocks ligand binding and thereby inhibits activation of PDGFRA kinase activity. Pre-clinically, this antibody inhibited PDGFRA-dependent tumor growth. In a randomized Phase… read more here.

Keywords: tissue sarcoma; soft tissue; pdgfra; antibody ... See more keywords
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Association of MTOR and PDGFRA gene polymorphisms with different degrees of myopia severity.

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recommendations! Published in 2022 at "Experimental eye research"

DOI: 10.1016/j.exer.2022.108962

Abstract: This study aims to investigate the associations of SNPs in the mammalian target of rapamycin (MTOR) and the platelet derived growth factor receptor alpha (PDGFRA) genes with different degrees of myopia severity in Han and… read more here.

Keywords: pdgfra; degrees myopia; myopia severity; mtor ... See more keywords
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Pdgfra regulates multipotent cell differentiation towards chondrocytes via inhibiting Wnt9a/beta-catenin pathway during chondrocranial cartilage development.

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recommendations! Published in 2020 at "Developmental biology"

DOI: 10.1016/j.ydbio.2020.08.004

Abstract: The mammalian skull is composed of the calvarial bones and cartilages. Malformation of craniofacial cartilage has been identified in multiple human syndromes. However, the mechanisms of their development remain largely unknown. In the present study,… read more here.

Keywords: pdgfra; chondrocranial cartilage; differentiation; cartilage development ... See more keywords
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Autophagy in PDGFRA+ mesenchymal cells is required for intestinal homeostasis and mammalian survival

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2090694

Abstract: ABSTRACT Macroautophagy/autophagy defects are a risk factor for inflamatory bowel disease (IBD), but the mechanism remains unclear. We previously demonstrated that conditional whole-body deletion of the essential Atg7 (autophagy related 7) gene in adult mice… read more here.

Keywords: deletion; loss; mesenchymal cells; autophagy ... See more keywords
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A Novel USP25::PDGFRA Gene Fusion in a 78 Year Old Patient with a Myeloid Neoplasm.

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recommendations! Published in 2022 at "Laboratory medicine"

DOI: 10.1093/labmed/lmac010

Abstract: The World Health Organization category of myeloid/lymphoid neoplasms with eosinophilia and PDGFRA rearrangements is composed of a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, acute myeloid leukemia, myeloid sarcoma, or lymphoblastic… read more here.

Keywords: myeloid neoplasm; patient myeloid; novel usp25; myeloid ... See more keywords
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CSIG-06. PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA AS AN ONCOGENIC DRIVER IN GLIOBLASTOMA

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recommendations! Published in 2020 at "Neuro-oncology"

DOI: 10.1093/neuonc/noaa215.118

Abstract: Activated platelet derived growth factor receptor alpha (PDGFRα) is essential for the maintenance of oligodendrocyte progenitors. Differential signaling results from phosphorylation of specific tyrosine residues in the kinase insert (KI) domain present in most RTKs… read more here.

Keywords: pdgfra; ecdna; growth factor; activation ... See more keywords
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Oncogenic Long Non-coding RNA LINC02283 Enhances PDGF Receptor A mediated Signaling and Drives Glioblastoma Tumorigenesis.

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recommendations! Published in 2023 at "Neuro-oncology"

DOI: 10.1093/neuonc/noad065

Abstract: BACKGROUND Long non-coding RNAs (lncRNAs) regulate the etiology of complex diseases and cancers, including glioblastoma (GBM). However, lncRNA-based therapies are limited because the mechanisms of action of many lncRNAs with their binding partners are not… read more here.

Keywords: long non; linc02283; gbm; receptor ... See more keywords
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P11.54 Identification of PDGFRA and MYC(N) as somatic driver genes in Glioblastoma

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recommendations! Published in 2019 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noz126.200

Abstract: Somatic oncogene amplification happens frequently in glioblastoma (GBM). The second most frequently amplified gene encoding receptor tyrosine kinases in GBMs is platelet derived growth factor alpha (PDGFRA) (15%). In contrast, MYC and MYCN amplification occurs… read more here.

Keywords: pdgfra; expression; pdgfra myc; myc ... See more keywords
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Complete response of myeloid/lymphoid neoplasms with PDGFRA rearrangement presenting as leukemia/myeloid sarcoma to imatinib monotherapy

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recommendations! Published in 2019 at "Chinese Medical Journal"

DOI: 10.1097/cm9.0000000000000437

Abstract: of myeloperoxidase, CD34, and CD117. Blood tests To the Editor: The presence of FIP-1-like-1-platelet-derived growth factor receptor-a (FIP1L1-PDGFRA, F/P) fusion identified the presence of eosinophilia (3.86 10/L, 49.2% gene accounts for approximately 23% (3%–56%) of… read more here.

Keywords: myeloid; pdgfra; pdgfra rearrangement; myeloid lymphoid ... See more keywords