Immunohistochemical expression and localization of cytokines/chemokines/growth factors in gastric cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2016.08.032
Abstract: HighlightsWe analyzed cytokine//growth factor expression in gastric tumor & normal tissues.Expression of several markers was high in tumor stroma compared to normal stroma.PDGFRB and SPP1 emerged as potential prognostic factors in gastric cancer. ABSTRACT Our… read more here.
Keywords: gastric cancer; expression; factors gastric; growth ... See more keywords
Goat PDGFRB: unique mRNA expression profile in gonad and significant association between genetic variation and litter size
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DOI: 10.1098/rsos.180805
Abstract: β-Type platelet-derived growth factor receptor (PDGFRB) is a typical tyrosine kinase, as a candidate gene associated with reproduction. Its main roles include regulation of gonocytes (migration and proliferation) and of the cell cycle. The objectives… read more here.
Keywords: association; litter size; goat; expression ... See more keywords
Novel PDGFRB rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib
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DOI: 10.1101/mcs.a004440
Abstract: Infantile myofibromatosis (IM) is an aggressive neoplasm composed of myofibroblast-like cells in children. Although typically localized, it can also present as multifocal disease, which represents a challenge for effective treatment. IM has previously been linked… read more here.
Keywords: infantile myofibromatosis; pdgfrb rearrangement; pdgfrb; novel pdgfrb ... See more keywords
Abstract A31: A distinctive genomic and immunohistochemical profile for NOTCH3 and PDGFRB in infantile myofibroma with diagnostic and therapeutic implications
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca17-a31
Abstract: Infantile myofibromas (IM) are rare benign neoplasms thought to derive from perivascular myoid cells. The prognosis is generally good, although about one-third of cases with multicentric involvement will also have visceral involvement, and the prognosis… read more here.
Keywords: distinctive genomic; infantile myofibroma; case; genomic immunohistochemical ... See more keywords
Sustained Response to Imatinib in a Pediatric Patient with Concurrent Myeloproliferative Disease and Lymphoblastic Lymphoma Associated with a CCDC88C-PDGFRB Fusion Gene
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DOI: 10.1159/000495687
Abstract: Background: The WHO defined myeloid and lymphoid neoplasms (MLN) with eosinophilia associated with PDGFRB, PDGFRA, FGFR1 rearrangements as a new entity in 2016. PDGFRB-rearranged MLN sensitive to imatinib were described in adult patients. We report… read more here.
Keywords: response; pdgfrb fusion; ccdc88c pdgfrb; lymphoblastic lymphoma ... See more keywords
Somatic Mosaicism of a PDGFRB Activating Variant in Aneurysms of the Intracranial, Coronary, Aortic, and Radial Artery Vascular Beds.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Heart Association"
DOI: 10.1161/jaha.121.024289
Abstract: Background Activating variants in platelet-derived growth factor receptor beta (PDGFRB), including a variant we have previously described (p.Tyr562Cys [g.149505130T>C [GRCh37/hg19]; c.1685A>G]), are associated with development of multiorgan pathology, including aneurysm formation. To investigate the association… read more here.
Keywords: intracranial coronary; radial artery; tissue; artery ... See more keywords
A novel PDGFRB sequence variant in a family with a mild form of primary familial brain calcification: a case report and a review of the literature
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DOI: 10.1186/s12883-019-1292-8
Abstract: BackgroundPrimary familial brain calcification is a rare autosomal dominant or recessive neurodegenerative disease, characterized by bilateral brain calcifications in different areas of the brain. It is a clinically heterogeneous disease and patients are reported to… read more here.
Keywords: primary familial; brain calcification; brain; familial brain ... See more keywords
Multiple MYO18A-PDGFRB fusion transcripts in a myeloproliferative neoplasm patient with t(5;17)(q32;q11)
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DOI: 10.1186/s13039-017-0306-8
Abstract: BackgroundMyeloproliferative neoplasms (MPNs), typically defined by myeloid proliferation and eosinophilia, and are only rarely caused by platelet-derived growth factor receptor beta (PDGFRB) gene rearrangements.Case presentationHere, we report a unique case of MPN that is negative… read more here.
Keywords: myo18a pdgfrb; q32 q11; fusion; pdgfrb ... See more keywords
Myeloid/Lymphoid Neoplasm with PDGFRB Rearrangement with t(5;10)(q33;q22) Harboring a Novel Breakpoint of the CCDC6-PDGFRB Fusion Gene
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DOI: 10.2169/internalmedicine.3220-19
Abstract: Myeloid/lymphoid neoplasms with PDGFRB rearrangement are a distinct type of myeloid neoplasms that occur in association with rearrangement of PDGFRB at 5q32. The hematological features most often show prominent eosinophilia. We herein report a patient… read more here.
Keywords: pdgfrb fusion; pdgfrb rearrangement; fusion gene; myeloid lymphoid ... See more keywords
Detection of Experimental Colorectal Peritoneal Metastases by a Novel PDGFRβ-Targeting Nanobody
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DOI: 10.3390/cancers14184348
Abstract: Simple Summary Colorectal cancer can metastasize to multiple distant sites. Metastases growing within the peritoneal cavity cause a high degree of morbidity and are associated with very poor survival. Moreover, peritoneal metastases are difficult to… read more here.
Keywords: peritoneal metastases; colorectal peritoneal; detection; pdgfrb ... See more keywords