Mutant NPM1-Regulated FTO-Mediated m6A Demethylation Promotes Leukemic Cell Survival via PDGFRB/ERK Signaling Axis
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DOI: 10.3389/fonc.2022.817584
Abstract: Acute myeloid leukemia (AML) with nucleophosmin 1 (NPM1) mutations exhibits distinct biological and clinical features, accounting for approximately one-third of AML. Recently, the N6-methyladenosine (m6A) RNA modification has emerged as a new epigenetic modification to… read more here.
Keywords: leukemic cell; erk signaling; pdgfrb erk; signaling axis ... See more keywords