Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor.
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DOI: 10.1016/j.ejmech.2019.111906
Abstract: Protein disulfide isomerase (PDI, PDIA1) is an emerging therapeutic target in oncology. PDI inhibitors have demonstrated a unique propensity to selectively induce apoptosis in cancer cells and overcome resistance to existing therapies, although drug candidates… read more here.
Keywords: class; chemistry; pdi inhibitor; indene ... See more keywords