Protein disulfide-isomerase A3 knockdown attenuates oxidized low-density lipoprotein-induced oxidative stress, inflammation and endothelial dysfunction in human umbilical vein endothelial cells by downregulating activating transcription factor 2
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2018980
Abstract: ABSTRACT Atherosclerosis is a chronic inflammatory disease implicated in oxidative stress and endothelial dysfunction. Protein disulfide-isomerase A3 (PDIA3) has been reported to regulate oxidative stress and suppress inflammation. This study aimed to explore the function… read more here.
Keywords: stress; inflammation; oxidative stress; pdia3 ... See more keywords
Silencing of ER-resident oxidoreductase PDIA3 inhibits malignant biological behaviors of multidrug-resistant gastric cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmab101
Abstract: Glycosylation is a common posttranslational modification of proteins, which plays a role in the malignant transformation, growth, progression, chemoresistance, and immune response of tumors. Disulfide isomerase family A3 (PDIA3) specifically acts on newly synthesized glycoproteins… read more here.
Keywords: resistant gastric; mdr cells; gastric cancer; multidrug resistant ... See more keywords
PDIA3/ERp57 promotes a matrix-rich secretome that stimulates fibroblast adhesion through CCN2
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DOI: 10.1152/ajpcell.00258.2021
Abstract: The matricellular glycoprotein thrombospondin-1 (TSP1) has complex roles in the extracellular matrix (ECM) and at cell surfaces, but relatively little is known about its intracellular associations prior to secretion. To search for novel intracellular interactions… read more here.
Keywords: cell; pdia3 erp57; physiology; pdia3 mefs ... See more keywords
Expression of protein disulfide isomerase A3 precursor in colorectal cancer
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DOI: 10.2147/ott.s154452
Abstract: Introduction Over 20% of colorectal cancer (CRC) patients seek medical attention for the first time when they are in the advanced stages of CRC. Thus, early and reliable detection of CRC is critical to early… read more here.
Keywords: colorectal cancer; protein disulfide; expression; crc ... See more keywords
PDIA3 Expression Is Altered in the Limbic Brain Regions of Triple-Transgenic Mouse Model of Alzheimer’s Disease
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DOI: 10.3390/ijms24033005
Abstract: In the present study, we used a mouse model of Alzheimer’s disease (AD) (3×Tg-AD mice) to longitudinally analyse the expression level of PDIA3, a protein disulfide isomerase and endoplasmic reticulum (ER) chaperone, in selected brain… read more here.
Keywords: brain regions; age; pathology; pdia3 ... See more keywords