lncRNA‐PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12553
Abstract: Hepatocellular carcinoma (HCC) is a malignancy with one of the worst prognoses. Long noncoding RNA (lncRNA) are emerging as an important regulator of gene expression and function, leading to the development of cancer. The aim… read more here.
Keywords: hepatocellular carcinoma; hcc; pdpk2p; lncrna pdpk2p ... See more keywords
HIF‐1α plays an essential role in BMP9‐mediated osteoblast differentiation through the induction of a glycolytic enzyme, PDK1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30752
Abstract: Bone homeostasis is regulated by bone morphogenic proteins (BMPs), among which BMP9 is one of the most osteogenic. Here, we have found that BMP9 rapidly increases the protein expression of hypoxia‐inducible factor‐1α (HIF‐1α) in osteoblasts… read more here.
Keywords: pdk1; hif protein; expression; hif ... See more keywords
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23531
Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the deadliest human malignancies characterized by late‐stage diagnosis, drug resistance, and poor prognosis. Pyruvate dehydrogenase kinase 1 (PDK1) plays an important role in regulating the metabolic reprogramming… read more here.
Keywords: cell; pdk1; progression; squamous cell ... See more keywords
PDK1 promotes the inflammatory progress of fibroblast-like synoviocytes by phosphorylating RSK2.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2016.10.007
Abstract: This study investigated the role of PDK1 in inflammatory response which is initiated by TNF-α and analyzed the association between PDK1 and RSK2. TNF-α were added into MH7A cells to induce inflammation condition. Through overexpressing… read more here.
Keywords: mh7a cells; rsk2; pdk1; rsk2 pdk1 ... See more keywords
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.07.026
Abstract: ABSTRACT Targeting pyruvate dehydrogenase kinase 1 (PDK1) has been suggested as a potential anticancer strategy. 2,2‐dichloroacetophenone (DAP) is a PDK1 inhibitor exhibiting weak anticancer potency and poor selectivity. The current study describes the characterization of… read more here.
Keywords: dehydrogenase; dehydrogenase kinase; pdk1; anticancer ... See more keywords
Molecular Insights into the Regulation of 3-Phosphoinositide-Dependent Protein Kinase 1: Modeling the Interaction between the Kinase and the Pleckstrin Homology Domains
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02020
Abstract: The 3-phosphoinositide-dependent protein kinase 1 (PDK1) K465E mutant kinase can still activate protein kinase B (PKB) at the membrane in a phosphatidylinositol-3,4,5-trisphosphate (PIP3, PtdIns(3,4,5)P3) independent manner. To understand this new PDK1 regulatory mechanism, docking and… read more here.
Keywords: protein kinase; pdk1; kinase; dependent protein ... See more keywords
S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-28910-8
Abstract: Functioning as a master kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) plays a fundamental role in phosphorylating and activating protein kinases A, B and C (AGC) family kinases, including AKT. However, upstream regulation of PDK1 remains… read more here.
Keywords: s6k1 mediated; mediated phosphorylation; pdk1; phosphorylation pdk1 ... See more keywords
The lipid code-dependent phosphoswitch PDK1–D6PK activates PIN-mediated auxin efflux in Arabidopsis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Plants"
DOI: 10.1038/s41477-020-0648-9
Abstract: Directional intercellular transport of the phytohormone auxin mediated by PIN-FORMED (PIN) efflux carriers has essential roles in both coordinating patterning processes and integrating multiple external cues by rapidly redirecting auxin fluxes. PIN activity is therefore… read more here.
Keywords: arabidopsis; d6pk; lipid code; pdk1 ... See more keywords
PDK1 Regulates the Lengthening of G1 Phase to Balance RGC Proliferation and Differentiation during Cortical Neurogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Cerebral cortex"
DOI: 10.1093/cercor/bhab428
Abstract: During cortical development, the balance between progenitor self-renewal and neurogenesis is critical for determining the size/morphology of the cortex. A fundamental feature of the developing cortex is an increase in the length of G1 phase… read more here.
Keywords: phase; lengthening phase; neurogenesis; pdk1 ... See more keywords
Genetic inhibition of PDK1 robustly reduces plaque deposition and ameliorates gliosis in the 5×FAD mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12839
Abstract: Abundant recent evidence has shown that 3‐phosphoinositide‐dependent protein kinase 1 (PDK1) is activated in Alzheimer's disease (AD). However, it remains unknown whether inhibition of PDK1 in neurons may affect AD‐like pathology in animal models of… read more here.
Keywords: pathology; pdk1; alzheimer disease; inhibition pdk1 ... See more keywords
Cancer-derived IgG involved in cisplatin resistance through PTP-BAS/Src/PDK1/AKT signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Oral diseases"
DOI: 10.1111/odi.13583
Abstract: OBJECTIVES This study aimed to explore whether knockdown of cancer-derived IgG (CIgG) could enhance cisplatin-induced anticancer effects. MATERIALS AND METHODS CIgG was knocked down by siRNA or Tet-on shRNA in the absence or presence of… read more here.
Keywords: ptp bas; cisplatin; src; pdk1 ... See more keywords