Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12558
Abstract: Abstract Background Muscle wasting, resulting from aging or pathological conditions, leads to reduced quality of life, increased morbidity, and increased mortality. Much research effort has been focused on the development of exercise mimetics to prevent… read more here.
Keywords: indoprofen; muscle; activation pdk1; muscle wasting ... See more keywords
Baicalin Inhibits EMT through PDK1/AKT Signaling in Human Nonsmall Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Oncology"
DOI: 10.1155/2021/4391581
Abstract: Background Baicalin is a naturally occurring compound with anticancer, antioxidant, and anti-inflammatory properties. However, the mechanism underlying its anticancer activity on nonsmall cell lung cancer (NSCLC) remains unclear. Methods The effects of baicalin on the… read more here.
Keywords: cell lung; pdk1 akt; cell; lung cancer ... See more keywords
Isosteviol attenuates DSS-induced colitis by maintaining intestinal barrier function through PDK1/AKT/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "International immunopharmacology"
DOI: 10.2139/ssrn.4178915
Abstract: Inflammatory bowel diseases (IBD) are chronic debilitating inflammatory disorders of the gastrointestinal tract that is characterized by intestinal epithelial barrier dysfunction and excessive activation of the mucosal immune system. Isosteviol (IS) has been reported to… read more here.
Keywords: barrier function; signaling pathway; intestinal barrier; barrier ... See more keywords
Sodium New Houttuyfonate Induces Apoptosis of Breast Cancer Cells via ROS/PDK1/AKT/GSK3β Axis
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DOI: 10.3390/cancers15051614
Abstract: Simple Summary Breast cancer treatment has long been a problem plaguing women’s health. In order to explore whether sodium new houttuyfonate (SNH) has a potential therapeutic effect on breast cancer, this study jointly demonstrated that… read more here.
Keywords: sodium new; breast cancer; new houttuyfonate; cancer ... See more keywords