lncRNA GAS5 suppresses rheumatoid arthritis by inhibiting miR-361-5p and increasing PDK4.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.10.040
Abstract: Rheumatoid arthritis (RA) is an inflammatory disease that causes hyperplasia of synovial tissue and cartilage destruction. This research was to investigate the effects of lncRNA GAS5/miR-361-5p/PDK4 on rheumatoid arthritis. By qRT-PCR, GAS5 and PDK4 were… read more here.
Keywords: lncrna gas5; pdk4; rheumatoid arthritis; mir 361 ... See more keywords
N6-methyladenosine regulates glycolysis of cancer cells through PDK4
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16306-5
Abstract: Studies on biological functions of N6-methyladenosine (m6A) modification in mRNA have sprung up in recent years. We find m6A can positively regulate the glycolysis of cancer cells. Specifically, m6A-sequencing and functional studies confirm that pyruvate… read more here.
Keywords: pdk4; regulates glycolysis; cancer cells; cancer ... See more keywords
Noncanonical PDK4 action alters mitochondrial dynamics to affect the cellular respiratory status
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120157119
Abstract: Significance Sustained energy stress and cellular dysfunction can cause excessive mitochondrial fragmentation, a feature observed in metabolic diseases, cancer, cardiovascular and neurological disorders, as well as in diseases associated with mitochondrial DNA mutations. We now… read more here.
Keywords: mitochondrial dynamics; respiratory status; pdk4; cellular respiratory ... See more keywords
lncRNA MEG3 Promotes PDK4/GSK-3β/β-Catenin Axis in MEFs by Targeting miR-532-5p
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/3563663
Abstract: Studies reported the positive and negative osteogenic effects of MEG3 in mesenchymal stem cells (MSCs). This study aims at clarifying the osteogenic potential of MEG3 and the underlying mechanism. Bone morphogenetic protein 9- (BMP9-) transfected… read more here.
Keywords: gsk catenin; meg3; pdk4; mir 532 ... See more keywords
Abstract 361: PDK4 is dispensable for PDAC chachexia
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-361
Abstract: Cachexia is an involuntary weight loss and muscle wasting that affects up to 80% of advanced cancer patients. It is an independent prognostic marker for response to treatment and overall survival and accounts for 20%… read more here.
Keywords: pdk4; muscle; pdk4 dispensable; pdac ... See more keywords
Difference in pyruvic acid metabolism between neonatal and adult mouse lungs exposed to hyperoxia
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0238604
Abstract: Objective Neonatal lungs are more tolerant to hyperoxic injury than are adult lungs. This study investigated differences in the response to hyperoxic exposure between neonatal and adult mouse lungs using metabolomics analysis with capillary electrophoresis… read more here.
Keywords: adult; pdk4; adult mouse; adult mice ... See more keywords
PDK4 protein interacts with Hmgcs2 to facilitate high glucose-induced myocardial injuries.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524023666221021124202
Abstract: OBJECTIVES As a distinct type of cardiomyopathy, diabetic cardiomyopathy (DCM) is featured as diastolic or systolic cardiac dysfunction in diabetic patients. In order to broaden the understanding of molecular mechanisms in DCM, we intended to… read more here.
Keywords: pdk4 hmgcs2; pdk4; pdk4 protein; high glucose ... See more keywords
Increased Expression of PDK4 Was Displayed in Gastric Cancer and Exhibited an Association With Glucose Metabolism
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.689585
Abstract: Previous studies reported that pyruvate dehydrogenase kinase 4 (PDK4) is closely related to diabetes, heart disease, and carcinomas. Nevertheless, the role of PDK4 in gastric cancer (GC) occurrence and development is yet poorly understood. Our… read more here.
Keywords: expression pdk4; pdk4; gastric cancer; pdk4 displayed ... See more keywords
PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.862316
Abstract: We recently showed that melatonin ameliorates the severity of experimental autoimmune encephalomyelitis (EAE), an animal model of MS. However, efficiency of melatonin therapy was associated with side effects, manifested by slowing down of remyelination, through… read more here.
Keywords: pdk4; remyelination; therapy; melatonin therapy ... See more keywords
Loss of PDK4 expression promotes proliferation, tumorigenicity, motility and invasion of hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer"
DOI: 10.7150/jca.43459
Abstract: Although the roles and underlying mechanisms of other PDK family members (i.e., PDK1, PDK2 and PDK3) in tumor progression have been extensively investigated and are well understood, the functions and underlying molecular mechanisms of pyruvate… read more here.
Keywords: hepatocellular carcinoma; hcc; pdk4; invasion ... See more keywords