Evaluation of PDL1 positive cancer cell‐specific binding activity of recombinant anti‐PDL1 scFv
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Progress"
DOI: 10.1002/btpr.3439
Abstract: Programmed cell death‐ligand 1 (PDL1) is a transmembrane protein that is characterized as an immune regulatory molecule. We recently developed a recombinant single‐chain fragment of variable domain (scFv) against PDL1, which showed high binding efficiency… read more here.
Keywords: pdl1 scfv; anti pdl1; pdl1 positive; cell ... See more keywords
Ultrasound Guided Local Delivery of Bioorthogonal PDL1 Degrader for Enhanced Immunotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202405549
Abstract: Immunotherapy involving PDL1 degradation holds great potential in anti‐tumor treatment. Optimal design of PDL1 degraders and subsequent efficient delivery into tumors are essential for expected efficacy, especially when abnormal tumor vasculature is considered. Herein, a… read more here.
Keywords: pdl1 degrader; ultrasound guided; delivery; tumor ... See more keywords
Epstein–Barr virus recruits PDL1-positive cells at the microenvironment in pediatric Hodgkin lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02787-2
Abstract: Classic Hodgkin lymphoma (cHL) is a lymphoid malignancy in which the microenvironment, where the neoplastic cells are immersed, contributes to the lymphomagenesis process. Epstein–Barr virus (EBV) presence also influences cHL microenvironment composition and contributes to… read more here.
Keywords: epstein barr; hodgkin lymphoma; pdl1; chl ... See more keywords
Nanobody against PDL1
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Letters"
DOI: 10.1007/s10529-020-02823-2
Abstract: Programmed death ligand 1 (PDL1, CD274, B7-H1) has been identified as the ligand for the immune inhibitory receptor programmed death 1 protein (PD1/PDCD1). PDL1 is a member of B7 family of immune molecules and this… read more here.
Keywords: nanobody pdl1; pdl1;
PDL1 high expression without TP53, KEAP1 and EPHA5 mutations could better predict survival for patients with NSCLC receiving atezolizumab.
Sign Up to like & getrecommendations! Published in 2020 at "Lung cancer"
DOI: 10.1016/j.lungcan.2020.11.006
Abstract: BACKGROUND Non-small cell lung cancer (NSCLC) patients with high expression of PDL1 are more likely to benefit from atezolizumab. There are no relevant research focusing on the relationship between the PDL1 expression and clinical variables… read more here.
Keywords: pdl1; epha5; expression; gene ... See more keywords
Caractérisation du statut PDL1 sur cellules tumorales circulantes et sur tissu tumoral comme biomarqueur de réponse à l’immunothérapie dans le carcinome bronchique non à petites cellules
Sign Up to like & getrecommendations! Published in 2019 at "Revue des Maladies Respiratoires"
DOI: 10.1016/j.rmr.2018.10.254
Abstract: Introduction Les inhibiteurs des points de controles immunitaires (IPCI) ont modifie la prise en charge des carcinomes bronchiques pulmonaires non a petites cellules (CBNPC). Le biomarqueur de la reponse aux IPCI est actuellement le taux… read more here.
Keywords: sur; pdl1 sur; statut pdl1; ctc ... See more keywords
Therapeutic efficacy of PD1/PDL1 blockade in B16 melanoma is greatly enhanced by immunization with dendritic cell-targeting lentiviral vector and protein vaccine.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.02.034
Abstract: While immune checkpoint inhibition is rapidly becoming standard of care in many solid tumors, immune checkpoint inhibitors (ICIs) fail to induce clinical responses in many patients, presumably due to insufficient numbers of tumor-specific T cells… read more here.
Keywords: pd1; pdl1; blockade; vaccine ... See more keywords
Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Oral Science"
DOI: 10.1038/s41368-024-00311-1
Abstract: Dysregulated Epiregulin (EREG) can activate epidermal growth factor receptor (EGFR) and promote tumor progression in head and neck squamous cell carcinoma (HNSCC). However, the mechanisms underlying EREG dysregulation remain largely unknown. Here, we showed that… read more here.
Keywords: ereg; stt3b mediated; hnscc; pdl1 ... See more keywords
Agreement between PDL1 immunohistochemistry assays and polymerase chain reaction in non-small cell lung cancer: CLOVER comparison study
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60950-2
Abstract: The goal of the CLOVER study was to perform a pairwise comparison of four tests based on the same patient population with non-small cell lung cancer (NSCLC): three validated PDL1 immunohistochemistry (IHC) assays (Ventana SP142,… read more here.
Keywords: non small; pdl1; ihc; pcr ... See more keywords
The Protective and Immunomodulatory Effects of Fucoidan Against 7,12-Dimethyl benz[a]anthracene-Induced Experimental Mammary Carcinogenesis Through the PD1/PDL1 Signaling Pathway in Rats
Sign Up to like & getrecommendations! Published in 2017 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2017.1362446
Abstract: ABSTRACT Fucoidan is a sulfated polysaccharide that is extracted from brown algae seaweed. This study was designed to evaluate the protective and immunomodulatory effects of dietary fucoidan on 7,12-dimethyl benz[a]anthracene (DMBA)-induced experimental mammary carcinogenesis in… read more here.
Keywords: protective immunomodulatory; pdl1; fucoidan; mammary carcinogenesis ... See more keywords
Comprehensive assessment of anti-tumour PDL1 blockade effect in a sarcoma mouse model
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz452.005
Abstract: Abstract Background Development of novel immunotherapeutics in oncology is of crucial interest and their good testing at preclinical stage relies on i) the features of the animal model used and ii) the application of an… read more here.
Keywords: pdl1 blockade; pdl1; effect; model ... See more keywords