Epstein–Barr virus recruits PDL1-positive cells at the microenvironment in pediatric Hodgkin lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02787-2
Abstract: Classic Hodgkin lymphoma (cHL) is a lymphoid malignancy in which the microenvironment, where the neoplastic cells are immersed, contributes to the lymphomagenesis process. Epstein–Barr virus (EBV) presence also influences cHL microenvironment composition and contributes to… read more here.
Keywords: epstein barr; hodgkin lymphoma; pdl1; chl ... See more keywords
Nanobody against PDL1
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Letters"
DOI: 10.1007/s10529-020-02823-2
Abstract: Programmed death ligand 1 (PDL1, CD274, B7-H1) has been identified as the ligand for the immune inhibitory receptor programmed death 1 protein (PD1/PDCD1). PDL1 is a member of B7 family of immune molecules and this… read more here.
Keywords: nanobody pdl1; pdl1;
PDL1 high expression without TP53, KEAP1 and EPHA5 mutations could better predict survival for patients with NSCLC receiving atezolizumab.
Sign Up to like & getrecommendations! Published in 2020 at "Lung cancer"
DOI: 10.1016/j.lungcan.2020.11.006
Abstract: BACKGROUND Non-small cell lung cancer (NSCLC) patients with high expression of PDL1 are more likely to benefit from atezolizumab. There are no relevant research focusing on the relationship between the PDL1 expression and clinical variables… read more here.
Keywords: pdl1; epha5; expression; gene ... See more keywords
Caractérisation du statut PDL1 sur cellules tumorales circulantes et sur tissu tumoral comme biomarqueur de réponse à l’immunothérapie dans le carcinome bronchique non à petites cellules
Sign Up to like & getrecommendations! Published in 2019 at "Revue des Maladies Respiratoires"
DOI: 10.1016/j.rmr.2018.10.254
Abstract: Introduction Les inhibiteurs des points de controles immunitaires (IPCI) ont modifie la prise en charge des carcinomes bronchiques pulmonaires non a petites cellules (CBNPC). Le biomarqueur de la reponse aux IPCI est actuellement le taux… read more here.
Keywords: sur; pdl1 sur; statut pdl1; ctc ... See more keywords
Therapeutic efficacy of PD1/PDL1 blockade in B16 melanoma is greatly enhanced by immunization with dendritic cell-targeting lentiviral vector and protein vaccine.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.02.034
Abstract: While immune checkpoint inhibition is rapidly becoming standard of care in many solid tumors, immune checkpoint inhibitors (ICIs) fail to induce clinical responses in many patients, presumably due to insufficient numbers of tumor-specific T cells… read more here.
Keywords: pd1; pdl1; blockade; vaccine ... See more keywords
Agreement between PDL1 immunohistochemistry assays and polymerase chain reaction in non-small cell lung cancer: CLOVER comparison study
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60950-2
Abstract: The goal of the CLOVER study was to perform a pairwise comparison of four tests based on the same patient population with non-small cell lung cancer (NSCLC): three validated PDL1 immunohistochemistry (IHC) assays (Ventana SP142,… read more here.
Keywords: non small; pdl1; ihc; pcr ... See more keywords
The Protective and Immunomodulatory Effects of Fucoidan Against 7,12-Dimethyl benz[a]anthracene-Induced Experimental Mammary Carcinogenesis Through the PD1/PDL1 Signaling Pathway in Rats
Sign Up to like & getrecommendations! Published in 2017 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2017.1362446
Abstract: ABSTRACT Fucoidan is a sulfated polysaccharide that is extracted from brown algae seaweed. This study was designed to evaluate the protective and immunomodulatory effects of dietary fucoidan on 7,12-dimethyl benz[a]anthracene (DMBA)-induced experimental mammary carcinogenesis in… read more here.
Keywords: protective immunomodulatory; pdl1; fucoidan; mammary carcinogenesis ... See more keywords
Comprehensive assessment of anti-tumour PDL1 blockade effect in a sarcoma mouse model
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DOI: 10.1093/annonc/mdz452.005
Abstract: Abstract Background Development of novel immunotherapeutics in oncology is of crucial interest and their good testing at preclinical stage relies on i) the features of the animal model used and ii) the application of an… read more here.
Keywords: pdl1 blockade; pdl1; effect; model ... See more keywords
The Transient Display of a Chimeric PD-L1 Protein on Pancreatic Islets Promotes Indefinite Survival in Allogeneic Recipients
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/01.tp.0000543248.46167.ff
Abstract: Introduction and Objective Allogenic islet transplantation is an important therapeutic approach for the treatment of Type 1 Diabetes (T1D). However, graft rejection initiated and perpetuated by pathogenic T effector (Teff) cells presents a major barrier.… read more here.
Keywords: protein; pdl1; treatment; allogeneic ... See more keywords
Circ_0058058 Drives the Malignant Phenotypes and Immune Evasion of Pancreatic Cancer by the MicroRNA-557–Dependent Regulation of PDL1
Sign Up to like & getrecommendations! Published in 2022 at "Pancreas"
DOI: 10.1097/mpa.0000000000002205
Abstract: Objectives Pancreatic cancer (PC) is one of the most deadly malignancies in the world. Recently, circular RNAs play crucial roles in PC progression. However, the functions of circ_0058058 in PC are barely known. Methods The… read more here.
Keywords: circ 0058058; microrna 557; pdl1; pancreatic cancer ... See more keywords
Engineered anti-PDL1 with IFNα targets both immunoinhibitory and activating signals in the liver to break HBV immune tolerance
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DOI: 10.1136/gutjnl-2022-327059
Abstract: Objective The purpose of this study is to develop an anti-PDL1-based interferon (IFN) fusion protein to overcome the chronic hepatitis B virus (HBV)-induced immune tolerance, and combine this immunotherapy with a HBV vaccine to achieve… read more here.
Keywords: immune tolerance; pdl1; hbv; pdl1 ifn ... See more keywords