Abstract 2979: Deletion of p53-related protein kinase (TP53RK) suppresses solar UV-induced photocarcinogenesis by inhibiting PDL1 expression and enhancing CD8+ T cell infiltration
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-2979
Abstract: Nonmelanoma skin cancers (NMSCs), including cutaneous squamous cell carcinoma (cSCC), are primarily caused by solar ultraviolet (UV) exposure and represent the most common cancers in the United States. TP53RK (p53-related protein kinase, also known as… read more here.
Keywords: deletion; tp53rk; cell; pdl1 expression ... See more keywords
PDL1 Expression and Outcomes in Histiocytic Neoplasms
Sign Up to like & getrecommendations! Published in 2025 at "Case Reports in Oncology"
DOI: 10.1159/000546447
Abstract: Abstract Introduction: Histiocytic sarcoma (HS) and interdigitating dendritic cell sarcoma (IDCS) are both extremely rare and aggressive histiocytic neoplasms that are most often treated with lymphoma-based chemotherapy; however, there is growing use of immune checkpoint… read more here.
Keywords: expression outcomes; pdl1 expression; histiocytic neoplasms; case ... See more keywords
Analysis of PDL1 expression and T cells infiltration in 1014 gastric cancer patients.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.50
Abstract: 50Background: Although immune checkpoint inhibitors have demonstrated promising results in melanoma and lung cancer, their effects on gastrointestinal cancer are still under investigation. Understand the prognostic effect of PDL1 expression, infiltration by CD8+ and CD3+… read more here.
Keywords: analysis pdl1; gastric cancer; pdl1 expression; infiltration ... See more keywords
Immunological correlates of response to immune checkpoint inhibitors (ICI) in metastatic urothelial carcinoma (mUC) patients (pts).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.6_suppl.454
Abstract: 454Background: Identification of biomarkers predictive of response to ICI could help guide treatment (tx) decisions. We assessed the correlation between PD1/PDL1 expression in key immunomodulatory subsets (myeloid-derived suppressor cells [MDSC]; CD8+ T cells) and tx… read more here.
Keywords: response; pd1 pdl1; pdl1 expression; mdsc ... See more keywords
Microbe-Mediated Activation of Toll-like Receptor 2 Drives PDL1 Expression in HNSCC
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13194782
Abstract: Simple Summary Tumors use immunosuppressive signals to evade detection by the immune system. While recurrent and metastatic head and neck squamous cell carcinoma has historically carried a poor prognosis, therapies targeting the immunosuppressive PD1:PDL1 axis… read more here.
Keywords: toll like; tlr2; pdl1 expression; hnscc ... See more keywords
Programmed Death Ligand-1 Expression in Gliomas: A Study of Histopathological and Molecular Associations
Sign Up to like & getrecommendations! Published in 2021 at "Neurology India"
DOI: 10.4103/0028-3886.325352
Abstract: Background: Gliomas are aggressive tumors with limited treatment options. Immunotherapy targets are under evaluation as new therapeutic targets in gliomas. Aims and Objectives: The aims of the study were to analyze expression of PDL1 in… read more here.
Keywords: gliomas; pdl1 expression; study; programmed death ... See more keywords