Periodontal ligament stem cells promote polarization of M2 macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.1ma1220-853rr
Abstract: Macrophages are widely distributed in a variety of tissues, and the different state of macrophages polarization is closely related to the occurrence, development, and prognosis of inflammation, including periodontitis, a chronic inflammatory disease leading to… read more here.
Keywords: pdlscs; stem cells; macrophage polarization; polarization ... See more keywords
Metabolomics Dysfunction in Replicative Senescence of Periodontal Ligament Stem Cells Regulated by AMPK Signaling Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Stem Cells and Development"
DOI: 10.1089/scd.2024.0112
Abstract: Periodontal ligament mesenchymal stem cells (PDLSCs) are a promising cell resource for stem cell-based regenerative medicine in dentistry, but they inevitably acquire a senescent phenotype after prolonged in vitro expansion. The key regulators of PDLSCs… read more here.
Keywords: senescence; replicative senescence; pdlscs; stem cells ... See more keywords
LncRNA LOXL1-AS1 inhibits proliferation of PDLSCs and downregulates IL-1β in periodontitis patients.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of periodontal research"
DOI: 10.1111/jre.12962
Abstract: BACKGROUND The carcinogenic role of lncRNA LOXL1-AS1 in thoracic aortic aneurysm has been confirmed, but its role in the pathogenesis of periodontitis remains unclear. Our preliminary deep sequencing data revealed LOXL1-AS1 downregulation in periodontitis and… read more here.
Keywords: pdlscs; periodontitis; loxl1 as1; proliferation ... See more keywords
Lipopolysaccharide from Escherichia coli stimulates osteogenic differentiation of human periodontal ligament stem cells through Wnt/&bgr;‐catenin–induced TAZ elevation
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oral Microbiology"
DOI: 10.1111/omi.12249
Abstract: Human periodontal ligament stem cells (PDLSCs), a type of dental tissue-derived mesenchymal stem cells (MSCs), can be clinically applied in periodontal tissue regeneration to treat periodontitis, which is initiated and sustained by bacteria. Lipopolysaccharide (LPS),… read more here.
Keywords: stem cells; coli; osteogenic differentiation; differentiation ... See more keywords
lncRNA CYTOR Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Modulating SOX11 via Sponging miR-6512-3p
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells International"
DOI: 10.1155/2023/5671809
Abstract: Periodontal ligament stem cells (PDLSCs) are considered ideal cell sources for the regeneration of periodontal and alveolar bone tissue. Cytoskeleton Regulator RNA (CYTOR), a newly discovered long noncoding RNA, has been reported to function as… read more here.
Keywords: pdlscs; osteogenic differentiation; cytor; mir 6512 ... See more keywords
Transient Receptor Potential Ankyrin 1 (TRPA1) Mediated LPS-Induced Inflammation in Periodontal Ligament Stem Cells by Inhibiting the Phosphorylation of JNK
Sign Up to like & getrecommendations! Published in 2024 at "Stem Cells International"
DOI: 10.1155/sci/7461604
Abstract: Transient receptor potential ankyrin 1 (TRPA1) molecule is an important type of transient receptor potential (TRP) cation channels, which can cause extracellular Ca2+ to flow into cells after activation. TRPA1 plays an important role in… read more here.
Keywords: jnk; trpa1; receptor potential; pdlscs ... See more keywords
UCHL1 Impairs Periodontal Ligament Stem Cell Osteogenesis in Periodontitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dental Research"
DOI: 10.1177/00220345221116031
Abstract: Periodontitis comprises a series of inflammatory responses resulting in alveolar bone loss. The suppression of osteogenesis of periodontal ligament stem cells (PDLSCs) by inflammation is responsible for impaired alveolar bone regeneration, which remains an ongoing… read more here.
Keywords: inflammation; pdlscs; alveolar bone; osteogenesis ... See more keywords
miR-589-3p promoted osteogenic differentiation of periodontal ligament stem cells through targeting ATF1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-022-03000-z
Abstract: Background An increasing number of studies have shown that dysregulated miR-589-3p is associated with multiple diseases. However, the role of miR-589-3p in osteogenic differentiation of periodontal ligament stem cells (PDLSCs) remains unknown. This study aimed… read more here.
Keywords: mir 589; expression; osteogenic differentiation; pdlscs ... See more keywords
Necrostatin-1 promotes ectopic periodontal tissue like structure regeneration in LPS-treated PDLSCs
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0207760
Abstract: Necroptosis is a programmed necrosis, regulated by receptor interacting protein kinase 1(RIP1) and receptor interacting protein kinase 3(RIP3), and could be inhibited by necrostatin-1(Nec-1) specifically. This study aims to evaluate the effect of Nec-1 on… read more here.
Keywords: like structure; lps treated; periodontal tissue; treated pdlscs ... See more keywords
Human periodontal ligament stem cells with distinct osteogenic potential induce bone formation in rat calvaria defects.
Sign Up to like & getrecommendations! Published in 2022 at "Regenerative medicine"
DOI: 10.2217/rme-2021-0178
Abstract: Aim: This study aimed to evaluate the ability of human periodontal ligament stem cells (PDLSCs) with high (HP-PDLSCs) and low (LP-PDLSCs) osteogenic potential, in addition to mixed cells, to repair bone tissue. Methods: Cell phenotype,… read more here.
Keywords: stem; bone formation; osteogenic potential; pdlscs ... See more keywords
Exosomes Derived From Human Gingival Mesenchymal Stem Cells Attenuate the Inflammatory Response in Periodontal Ligament Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.863364
Abstract: This study aimed to explore the effects of exosomes derived from human gingival mesenchymal stem cells (GMSC-Exo) on the inflammatory response of periodontal ligament stem cells (PDLSCs) in an inflammatory microenvironment in order to restore… read more here.
Keywords: inflammatory response; stem cells; pdlscs; stem ... See more keywords