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   Articles with "pdna" as a keyword



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Targeted DNA delivery to cancer cells using a biotinylated chitosan carrier

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recommendations! Published in 2017 at "Biotechnology and Applied Biochemistry"

DOI: 10.1002/bab.1497

Abstract: A novel biotinylated chitosan‐graft‐polyethyleneimine (Bio‐Chi‐g‐PEI) copolymer was synthesized and evaluated as a nonviral gene delivery carrier for improvement of the transfection efficiency, endosomal escape, and targeted gene delivery of a plasmid encoding green fluorescent protein… read more here.

Keywords: delivery; pdna complexes; bio chi; chi pei ... See more keywords
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Analytical separation of plasmid DNA isoforms using anion exchanging chromatographic monoliths with 6 µm channels.

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recommendations! Published in 2023 at "Electrophoresis"

DOI: 10.1002/elps.202300031

Abstract: High-performance liquid chromatography (HPLC)-based analytical assays are used to effectively monitor purity and quantity of plasmid DNA (pDNA) throughout the purification process. However, the phenomenon of physical entrapment of open circular (OC) isoforms pDNA inside… read more here.

Keywords: plasmid dna; anion exchanging; analytical separation; pdna ... See more keywords
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EGFR Targeting and Shielding of pDNA Lipopolyplexes via Bivalent Attachment of a Sequence-Defined PEG Agent.

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recommendations! Published in 2018 at "Macromolecular bioscience"

DOI: 10.1002/mabi.201700203

Abstract: For successful nonviral gene delivery, cationic polymers are promising DNA carrier, which need to comprise several functionalities. The current work focuses on the postincorporation of epidermal growth factor receptor (EGFR) targeted PEGylation agents onto lipopolyplexes… read more here.

Keywords: sequence defined; agent; egfr targeting; sequence ... See more keywords

Zinc(II)-Dipicolylamine Analogs Mediated PEI1.8k/pDNA Vector: Effect of Ligand Structure on the Gene Transport Process.

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recommendations! Published in 2021 at "Macromolecular bioscience"

DOI: 10.1002/mabi.202100048

Abstract: Zinc ion complexes of dipicolylamine analogs, due to the strong synergistic effect between the Zn2+ complex of containing polypyridine derivatives and polycations in each key step of pDNA transport, have been used as the third… read more here.

Keywords: zinc; transport; dipicolylamine analogs; effect ... See more keywords
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Injectable nanofibrous spongy microspheres for NR4A1 plasmid DNA transfection to reverse fibrotic degeneration and support disc regeneration.

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recommendations! Published in 2017 at "Biomaterials"

DOI: 10.1016/j.biomaterials.2017.03.029

Abstract: Safe and efficient gene therapy is highly desired for controlling pathogenic fibrosis of nucleus pulposus (NP) tissue, which would result in intervertebral disc (IVD) degeneration and disability if left untreated. In this work, a hyperbranched… read more here.

Keywords: fibrosis; plasmid dna; spongy microspheres; nanofibrous spongy ... See more keywords
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Glycopolymers/PEI complexes as serum-tolerant vectors for enhanced gene delivery to hepatocytes.

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recommendations! Published in 2019 at "Carbohydrate polymers"

DOI: 10.1016/j.carbpol.2018.10.036

Abstract: Serum stability is a crucial factor for ideal polymeric gene vectors. In this work, a series of serum-tolerant and low-toxicity glycopolymers/poly(ethyleneimine) (PEI) complexes were designed for gene delivery. Atomic transfer radical polymerization (ATRP) was used… read more here.

Keywords: ddrls pei; delivery; pei; gene ... See more keywords
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Interaction of pDNA with reverse phase chitosome

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recommendations! Published in 2018 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"

DOI: 10.1016/j.colsurfa.2018.02.005

Abstract: Abstract The use of liposomes and polyelectrolytes is on scientific and technologic scrutiny for development of gene nano carriers. We produced a reverse phase lipid:chitosan “chitosome” to which plasmid DNA (pDNA) effectively interacts and compacts.… read more here.

Keywords: interaction pdna; reverse phase; plasmid; pdna ... See more keywords
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Electrospun gelatin matrices with bioactive pDNA polyplexes.

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recommendations! Published in 2020 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2020.01.252

Abstract: Recent advances in electrospinning are yielding intricate scaffolds for use in regenerative medicine. To explore the possibility of creating bioactive scaffolds with functional gene expression systems, electrospun gelatin mats bearing plasmid DNA (pDNA) polyplexes are… read more here.

Keywords: electrospun gelatin; pdna polyplexes; bioactive pdna; matrices bioactive ... See more keywords
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PEG modified trimethyl chitosan based nanoparticles for the codelivery of doxorubicin and iSur-pDNA

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recommendations! Published in 2019 at "Materials Letters"

DOI: 10.1016/j.matlet.2018.11.161

Abstract: Abstract Doxorubicin (DOX) is one of the commonly used chemotherapeutic agents, but its clinical use is restricted by systemic toxicity and tumor multidrug resistance. To overcome these barriers, PEG modified trimethyl chitosan based nanoparticles (NPs)… read more here.

Keywords: modified trimethyl; pdna; trimethyl chitosan; chitosan based ... See more keywords
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Facile Construction of a Two-in-One Injectable Micelleplex-Loaded Thermogel System for the Prolonged Delivery of Plasmid DNA.

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recommendations! Published in 2022 at "Biomacromolecules"

DOI: 10.1021/acs.biomac.2c00648

Abstract: Nanoparticle-hydrogel systems have recently emerged as a class of interesting hybrid materials with immense potential for several biomedical applications. Remarkably, the incorporation of nanoparticles into a hydrogel may yield synergistic benefits lacking in a singular… read more here.

Keywords: system; two one; pdna; system prolonged ... See more keywords
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Poly(ethylene glycol) Crowding as Critical Factor To Determine pDNA Packaging Scheme into Polyplex Micelles for Enhanced Gene Expression.

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recommendations! Published in 2017 at "Biomacromolecules"

DOI: 10.1021/acs.biomac.6b01247

Abstract: A critical role of polyethylene glycol (PEG) crowding in the packaging of plasmid DNA (pDNA) into polyplex micelles (PMs) was investigated using a series of PEG-b-poly(l-lysine) (PEG-PLys) block copolymers with varying molecular weights of both… read more here.

Keywords: gene expression; polyplex micelles; packaging; peg ... See more keywords