Developing patient-derived organoids to predict PARP inhibitor response and explore resistance overcoming strategies in ovarian cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.1016/j.phrs.2022.106232
Abstract: With the common use of poly ADP-ribose polymerase inhibitors (PARPi) for the man-agement of epithelial ovarian cancer (EOC) across the treatment life cycle, there is a critical need for the development of functional tests, as… read more here.
Keywords: response; derived organoids; ovarian cancer; resistance ... See more keywords
Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer
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DOI: 10.1097/sla.0000000000004200
Abstract: Supplemental Digital Content is available in the text Objective: PDAC patients who undergo surgical resection and receive effective chemotherapy have the best chance of long-term survival. Unfortunately, we lack predictive biomarkers to guide optimal systemic… read more here.
Keywords: medicine; precision medicine; patient derived; derived organoid ... See more keywords
TIMP1 promotes cell proliferation and invasion capability of right‐sided colon cancers via the FAK/Akt signaling pathway
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DOI: 10.1111/cas.15567
Abstract: Although right‐sided colorectal cancer (CRC) shows a worse prognosis than left‐sided CRC, the underlying mechanism remains unclear. We established patient‐derived organoids (PDOs) from left‐ and right‐sided CRCs and directly compared cell proliferation and invasion capability… read more here.
Keywords: pdos; cell proliferation; left sided; right sided ... See more keywords
Abstract LB219: DCLK1 is a novel therapeutic target for gastric and colorectal cancers as demonstrated by patient-derived organoids assays
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DOI: 10.1158/1538-7445.am2024-lb219
Abstract: Gastrointestinal cancers, including gastric cancer (GC) and colorectal cancer (CRC), continue to be devastating diseases despite advances in screening, early detection, and removal of pre-neoplastic and early cancerous lesions. Even with advancements in targeted chemotherapy… read more here.
Keywords: patient derived; dclk1; tumor; car cells ... See more keywords
Abstract A21: Utilizing endoscopic-derived gastric cancer organoids for personalized neoadjuvant chemotherapy
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DOI: 10.1158/1538-7445.camodels2020-a21
Abstract: Introduction: Patient-derived organoids (PDOs) have become attractive tools for genetic studies, biomarker identification, drug screening, and preclinical evaluation of personalized medicine strategies. Previously, we created gastric cancer PDOs from esophagogastroduodenoscopy (EGD) biopsy specimens. As a… read more here.
Keywords: chemotherapy; gastric cancer; derived gastric; drug ... See more keywords
Renin–Angiotensin Inhibitor, Captopril, Attenuates Growth of Patient-Derived Colorectal Liver Metastasis Organoids
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DOI: 10.3390/ijms25063282
Abstract: The recurrence of colorectal liver metastasis (CRLM) following liver resection is common; approximately 40% of patients will experience tumor recurrence post-surgery. Renin–angiotensin inhibitors (RASis) have been shown to attenuate the growth and progression of CRLM… read more here.
Keywords: crlm; colorectal liver; liver; liver metastasis ... See more keywords