Treating Pain in Diabetic Neuropathy: Current and Developmental Drugs
Sign Up to like & getrecommendations! Published in 2020 at "Drugs"
DOI: 10.1007/s40265-020-01259-2
Abstract: There is a high prevalence of painful diabetic polyneuropathy (pDPN) with around one-third of all patients with diabetes suffering from pDPN. pDPN has debilitating consequences, with a major impact on morbidity and quality of life.… read more here.
Keywords: treating pain; pdpn; diabetic neuropathy; drugs treating ... See more keywords
Podoplanin promotes cancer-associated thrombosis and contributes to the unfavorable overall survival in an ectopic xenograft mouse model of oral cancer
Sign Up to like & getrecommendations! Published in 2019 at "Biomedical Journal"
DOI: 10.1016/j.bj.2019.07.001
Abstract: Background Podoplanin (PDPN) is a transmembrane glycoprotein that mediates tumor cell-induced platelets aggregation in different cancer types. Emerging data indicate that PDPN is a marker for poor prognosis of human oral squamous cell carcinoma (OSCC).… read more here.
Keywords: pdpn; cancer; cancer associated; associated thrombosis ... See more keywords
TMIC-27. PDPN ACTIVATION OF CLEC5A IN THE PERI-NECROTIC NICHE DRIVES TAM POLARIZATION AND TME IMMUNOSUPPRESSION IN GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.1205
Abstract: Glioblastoma, IDH-wildtype (GBM, WHO grade 4) is the most common malignant glioma of adults and is characterized by a severely hypoxic and immunosuppressive tumor microenvironment (TME). CLEC5A regulates immune responses in inflammatory and infectious diseases.… read more here.
Keywords: tam polarization; clec5a; pdpn; gbm ... See more keywords
Antitumor Activities by a Humanized Cancer‐Specific Anti‐Podoplanin Monoclonal Antibody humPMab‐117 Against Human Tumors
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DOI: 10.1111/cas.70103
Abstract: Podoplanin (PDPN), also referred to as T1α/Aggrus, is a type I transmembrane sialoglycoprotein that plays a crucial role in invasiveness, stemness, and epithelial‐to‐mesenchymal transition, all of which contribute to the malignant progression of tumors. Therefore,… read more here.
Keywords: cancer specific; monoclonal antibody; humpmab 117; pdpn ... See more keywords
Targeting Podoplanin for the Treatment of Osteosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-4509
Abstract: Abstract Purpose: Osteosarcoma, the most common bone malignancy in children, has a poor prognosis, especially when the tumor metastasizes to the lungs. Therefore, novel therapeutic strategies targeting both proliferation and metastasis of osteosarcoma are required.… read more here.
Keywords: metastasis; osteosarcoma; growth; pdpn ... See more keywords
Abstract SY36-02: Interrogating how the dialogue between immune cells and fibroblasts impacts radiotherapy outcomes
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-sy36-02
Abstract: Increased stromal fibroblasts in tumors is associated with inferior radiotherapy responses, however, we lack a mechanistic understanding of how fibroblast reprogramming contributes to radiotherapy outcomes. Methods: Radiotherapy (8Gy) was applied to 5555 BRAF mutant melanoma… read more here.
Keywords: dialogue immune; interrogating dialogue; immune cells; radiotherapy outcomes ... See more keywords
Elevated Soluble Podoplanin Associates with Hypercoagulability in Patients with Nephrotic Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Applied Thrombosis/Hemostasis"
DOI: 10.1177/10760296221108967
Abstract: Podoplanin (PDPN) promotes platelet aggregation and activation by interacting with C-type lectin-like receptor 2(CLEC-2) on platelets. The interaction between the upregulated PDPN and platelet CLEC-2 stimulates venous thrombosis. PDPN was identified as a risk factor… read more here.
Keywords: hypercoagulability nephrotic; hypercoagulability; pdpn; nephrotic syndrome ... See more keywords
Platelet (hem)ITAM Signaling Mediated Cancer-Associated Venous Thrombosis
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DOI: 10.1182/blood-2018-99-116220
Abstract: Background-Patients with cancer are at a high risk of venous thromboembolism (VTE) and underlying mechanisms are unclear. Recent studies have shown that podoplanin (PDPN) expressing highly in primary brain tumors is associated with increasingly risk… read more here.
Keywords: pdpn; hem itam; platelet; cancer ... See more keywords
The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis
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DOI: 10.1186/s12885-024-12194-w
Abstract: Podoplanin (PDPN) expressed on tumour cells interacts with platelet C-type lectin-like receptor 2 (CLEC-2). This study aimed to investigate the role of the PDPN-platelet CLEC-2 interaction in melanoma pulmonary metastasis. Murine melanoma B16-F0 cells, which… read more here.
Keywords: clec; pdpn; melanoma; pulmonary metastasis ... See more keywords
Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16311
Abstract: Podoplanin (PDPN), an O-glycosylated, transmembrane, mucin-type glycoprotein, is expressed by cancer associated fibroblasts (CAFs). In malignant transformation, PDPN is subjected to changes and its role is yet to be established. Here we show that it… read more here.
Keywords: ccl21 ccr7; pdpn; ccr7; ccl21 ... See more keywords
Correlation Between Expression of Twist and Podoplanin in Ductal Breast Carcinoma.
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DOI: 10.21873/anticanres.11978
Abstract: BACKGROUND/AIM As a result of activation of transcription factors engaged in epithelial-mesenchymal transition (EMT), such as Twist, inhibition of epithelial markers and an increased expression of mesenchymal markers are observed. One of the specific markers… read more here.
Keywords: pdpn; stromal cells; expression twist; expression ... See more keywords