LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "pdpn" as a keyword



Photo by diabetesmagazijn from unsplash

Treating Pain in Diabetic Neuropathy: Current and Developmental Drugs

Sign Up to like & get
recommendations! Published in 2020 at "Drugs"

DOI: 10.1007/s40265-020-01259-2

Abstract: There is a high prevalence of painful diabetic polyneuropathy (pDPN) with around one-third of all patients with diabetes suffering from pDPN. pDPN has debilitating consequences, with a major impact on morbidity and quality of life.… read more here.

Keywords: treating pain; pdpn; diabetic neuropathy; drugs treating ... See more keywords
Photo from wikipedia

Podoplanin promotes cancer-associated thrombosis and contributes to the unfavorable overall survival in an ectopic xenograft mouse model of oral cancer

Sign Up to like & get
recommendations! Published in 2019 at "Biomedical Journal"

DOI: 10.1016/j.bj.2019.07.001

Abstract: Background Podoplanin (PDPN) is a transmembrane glycoprotein that mediates tumor cell-induced platelets aggregation in different cancer types. Emerging data indicate that PDPN is a marker for poor prognosis of human oral squamous cell carcinoma (OSCC).… read more here.

Keywords: pdpn; cancer; cancer associated; associated thrombosis ... See more keywords
Photo from wikipedia

Targeting Podoplanin for the Treatment of Osteosarcoma

Sign Up to like & get
recommendations! Published in 2022 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-21-4509

Abstract: Abstract Purpose: Osteosarcoma, the most common bone malignancy in children, has a poor prognosis, especially when the tumor metastasizes to the lungs. Therefore, novel therapeutic strategies targeting both proliferation and metastasis of osteosarcoma are required.… read more here.

Keywords: metastasis; osteosarcoma; growth; pdpn ... See more keywords

Elevated Soluble Podoplanin Associates with Hypercoagulability in Patients with Nephrotic Syndrome

Sign Up to like & get
recommendations! Published in 2022 at "Clinical and Applied Thrombosis/Hemostasis"

DOI: 10.1177/10760296221108967

Abstract: Podoplanin (PDPN) promotes platelet aggregation and activation by interacting with C-type lectin-like receptor 2(CLEC-2) on platelets. The interaction between the upregulated PDPN and platelet CLEC-2 stimulates venous thrombosis. PDPN was identified as a risk factor… read more here.

Keywords: hypercoagulability nephrotic; hypercoagulability; pdpn; nephrotic syndrome ... See more keywords
Photo by hacker723 from unsplash

Platelet (hem)ITAM Signaling Mediated Cancer-Associated Venous Thrombosis

Sign Up to like & get
recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-116220

Abstract: Background-Patients with cancer are at a high risk of venous thromboembolism (VTE) and underlying mechanisms are unclear. Recent studies have shown that podoplanin (PDPN) expressing highly in primary brain tumors is associated with increasingly risk… read more here.

Keywords: pdpn; hem itam; platelet; cancer ... See more keywords

Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization

Sign Up to like & get
recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.16311

Abstract: Podoplanin (PDPN), an O-glycosylated, transmembrane, mucin-type glycoprotein, is expressed by cancer associated fibroblasts (CAFs). In malignant transformation, PDPN is subjected to changes and its role is yet to be established. Here we show that it… read more here.

Keywords: ccl21 ccr7; pdpn; ccr7; ccl21 ... See more keywords
Photo by ospanali from unsplash

Correlation Between Expression of Twist and Podoplanin in Ductal Breast Carcinoma.

Sign Up to like & get
recommendations! Published in 2017 at "Anticancer research"

DOI: 10.21873/anticanres.11978

Abstract: BACKGROUND/AIM As a result of activation of transcription factors engaged in epithelial-mesenchymal transition (EMT), such as Twist, inhibition of epithelial markers and an increased expression of mesenchymal markers are observed. One of the specific markers… read more here.

Keywords: pdpn; stromal cells; expression twist; expression ... See more keywords
Photo from wikipedia

Podoplanin: A potential therapeutic target for thrombotic diseases

Sign Up to like & get
recommendations! Published in 2023 at "Frontiers in Neurology"

DOI: 10.3389/fneur.2023.1118843

Abstract: As a specific lymphatic marker and a key ligand of C-type lectin-like receptor 2 (CLEC-2), podoplanin (Pdpn) is involved in various physiological and pathological processes such as growth and development, respiration, blood coagulation, lymphangiogenesis, angiogenesis,… read more here.

Keywords: therapeutic target; thrombotic diseases; target thrombotic; pdpn ... See more keywords
Photo by aaronburden from unsplash

The Study of the Association of Polymorphisms in LSP1, GPNMB, PDPN, TAGLN, TSPO, and TUBB6 Genes with the Risk and Outcome of Ischemic Stroke in the Russian Population

Sign Up to like & get
recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24076831

Abstract: To date, there has been great progress in understanding the genetic basis of ischemic stroke (IS); however, several aspects of the condition remain underexplored, including the influence of genetic factors on post-stroke outcomes and the… read more here.

Keywords: study association; pdpn; tagln; stroke ... See more keywords
Photo from wikipedia

Association of high PDPN expression with pulmonary metastasis of osteosarcoma and patient prognosis

Sign Up to like & get
recommendations! Published in 2019 at "Oncology Letters"

DOI: 10.3892/ol.2019.11053

Abstract: Podoplanin (PDPN) is an important positive regulator of platelet aggregation and functions as a lymphatic endothelial marker. PDPN has been observed to be expressed in human tumor tissues and various cancer cell lines. In the… read more here.

Keywords: high pdpn; pdpn; pdpn expression; pulmonary metastasis ... See more keywords