Overlapping coactivator function is required for transcriptional activation by the Candida glabrata Pdr1 transcription factor
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DOI: 10.1093/genetics/iyae115
Abstract: Abstract Azole resistance in the pathogenic yeast Candida glabrata is a serious clinical complication and increasing in frequency. The majority of resistant organisms have been found to contain a substitution mutation in the Zn2Cys6 zinc… read more here.
Keywords: transcription factor; coactivator; candida glabrata; pdr1 ... See more keywords
Azole-Resistant Alleles of ERG11 in Candida glabrata Trigger Activation of the Pdr1 and Upc2A Transcription Factors
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DOI: 10.1128/aac.02098-21
Abstract: Azoles, the most commonly used antifungal drugs, specifically inhibit the fungal lanosterol α-14 demethylase enzyme, which is referred to as Erg11. Inhibition of Erg11 ultimately leads to a reduction in ergosterol production, an essential fungal… read more here.
Keywords: pdr1; transcription; resistance; erg11 ... See more keywords