Two‐Photon Absorption Induced Cancer Immunotherapy Using Covalent Organic Frameworks
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DOI: 10.1002/adfm.202103056
Abstract: Immune checkpoint blockade therapy is revolutionizing the traditional treatment model of multiple tumor types, but remains ineffective for a large subset of patients. Photodynamic therapy (PDT) has been shown to induce cancer cell death and… read more here.
Keywords: cancer; two photon; pdt; therapy ... See more keywords
Bimetallic Nanozymes‐Integrated Parachute‐Like Au2Pt@PMO@ICG Janus Nanomotor with Dual Propulsion for Enhanced Tumor Penetration and Synergistic PTT/PDT/CDT Cancer Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202406059
Abstract: Nanocatalytic therapeutic agents with triple synergistic treatment modes of chemodynamic therapy (CDT), photothermal therapy (PTT) and photodynamic therapy (PDT) are emerging nanomaterials in malignancy treatment. Nevertheless, the passive diffusion and transport of nanomaterials result in… read more here.
Keywords: parachute like; therapy; tumor; cancer therapy ... See more keywords
Deciphering the Intrinsic Chemistry of Protein‐Enhanced Type I Photodynamic Processes
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DOI: 10.1002/adfm.202518174
Abstract: Type I photodynamic therapy (PDT) shows great potential in solving the hypoxia issue of tumor treatment by producing oxygen radicals in a less O2‐dependent way, attracting significant research attention. This work systematically investigates the recently… read more here.
Keywords: chemistry; deciphering intrinsic; intrinsic chemistry; protein ... See more keywords
Soft X-Ray Stimulated Lanthanide@MOF Nanoprobe for Amplifying Deep Tissue Synergistic Photodynamic and Antitumor Immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101174
Abstract: Combining photodynamic therapy (PDT) and immunotherapy has shown profound impact for synergistic treatment of malignant tumors. However, the shallow penetration depth of the traditional visible light activated PDT, immunosuppressive tumor microenvironment (TME), and poor immunogenicity… read more here.
Keywords: deep tissue; immunotherapy; ray; pdt ... See more keywords
Engineering H2O2 and O2 Self‐Supplying Nanoreactor to Conduct Synergistic Chemiexcited Photodynamic and Calcium‐Overloaded Therapy in Orthotopic Hepatic Tumors
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DOI: 10.1002/adhm.202201613
Abstract: Photodynamic therapy (PDT) is traditionally ineffective for deeply embedded tumors due to the poor penetration depth of the excitation light. Chemiluminescence resonance energy transfer (CRET) has emerged as a promising mode of PDT without external… read more here.
Keywords: calcium; overloaded therapy; therapy orthotopic; therapy ... See more keywords
Switchable ROS Scavenger/Generator for MRI‐Guided Anti‐Inflammation and Anti‐Tumor Therapy with Enhanced Therapeutic Efficacy and Reduced Side Effects
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DOI: 10.1002/adhm.202202043
Abstract: Photosensitizer in photodynamic therapy (PDT) accumulates in both tumor and adjacent normal tissue due to low selective biodistribution, results in undesirable side effect with limited clinic application. Herein, an intelligent nanoplatform is reported that selectively… read more here.
Keywords: scavenger generator; ros scavenger; normal tissue; tumor ... See more keywords
A General Molecular Structural Design for Highly Efficient Photopyroptosis that can be Activated within 10 s Irradiation
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DOI: 10.1002/adma.202401145
Abstract: Photopyroptosis is an emerging research branch of photodynamic therapy (PDT), whereas there remains a lack of molecular structural principles to fabricate photosensitizers for triggering a highly efficient pyroptosis. Herein, a general and rational structural design… read more here.
Keywords: photopyroptosis; highly efficient; structural design; molecular structural ... See more keywords
Thermally Activated Delayed Fluorescence‐Guided Photodynamic Therapy Through Skeleton‐Homologous Nanoparticles: a Rational Material Design for High‐Efficient and High‐Contrast Theranostics
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DOI: 10.1002/adma.202500236
Abstract: Although photoluminescence imaging‐guided photodynamic therapy (PDT) is promising for theranostics, it easily suffers from tissue autofluorescence and PDT photoproducts. To develop time‐resolved imaging (TRI)‐guided PDT with long‐lived emission pathways, like thermally activated delayed fluorescence (TADF),… read more here.
Keywords: tri; guided photodynamic; pdt; delayed fluorescence ... See more keywords
Synergistic Copper‐Coordination/Glutathione Reduction Drives an In Situ Type II‐to‐Type I Photodynamic Switch in Iridium‐Based Photosensitizer Nanocomposites for Potentiated Cancer Immunotherapy
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DOI: 10.1002/adma.202506349
Abstract: The clinical translation of photodynamic therapy (PDT) faces dual challenges of tumor hypoxia and antioxidant defense mechanisms. To address these limitations, herein tumor microenvironment (TME)‐adaptive nanoparticles are rationally designed that enable oxygen‐independent PDT while reprogramming… read more here.
Keywords: photosensitizer; glutathione; type; copper ... See more keywords
Amplifying T cell‐mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti‐PD1
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DOI: 10.1002/cbf.3925
Abstract: Photodynamic therapy (PDT) is nowadays widely employed in cancer treatment. We sought to assess the efficacy of combining PDT with anti‐programmed cell death protein 1 (PD1) and to investigate the associated mechanisms in nonsmall cell… read more here.
Keywords: cancer; anti pd1; pd1; lung ... See more keywords
Polypyridyl Ruthenium(II) Complexes with Red‐Shifted Absorption: New Promises in Photodynamic Therapy
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DOI: 10.1002/cbic.202100102
Abstract: In the field of cancer photodynamic therapy (PDT) research, development of metal‐based PDT drugs that can be used under red light exposure is the “holy grail” to achieve. This highlight highlighted few current literatures on… read more here.
Keywords: pdt; photodynamic therapy; shifted absorption; red shifted ... See more keywords