PDTAC: Targeted Photodegradation of GPX4 Triggers Ferroptosis and Potent Antitumor Immunity.
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DOI: 10.1021/acs.jmedchem.2c00855
Abstract: Targeted degradation of proteins, especially those regarded as undruggable or difficult to drug, attracts wide attention to develop novel therapeutic strategies. Glutathione peroxidase 4 (GPX4), the key enzyme regulating ferroptosis, is currently a target with… read more here.
Keywords: targeted photodegradation; gpx4; antitumor immunity; pdtac targeted ... See more keywords