CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC
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DOI: 10.1038/leu.2017.346
Abstract: CRISPR/Cas9 edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC read more here.
Keywords: edited nsg; pdx models; crispr cas9; mice pdx ... See more keywords
Patient-derived xenografts as in vivo models for research in urological malignancies
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DOI: 10.1038/nrurol.2017.19
Abstract: Lack of appropriate models that recapitulate the complexity and heterogeneity of urological tumours precludes most of the preclinical reagents that target urological tumours from receiving regulatory approval. Patient-derived xenograft (PDX) models are characterized by direct… read more here.
Keywords: urological malignancies; research; pdx models; derived xenografts ... See more keywords
NSG mice as hosts for oncological precision medicine
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DOI: 10.1038/s41374-019-0298-6
Abstract: Patient-derived xenograft (PDX) models have been rediscovered as meaningful research tool. By using severely immunodeficient mice, high-engraftment rates can be theoretically achieved, permitting clinical stratification strategies. Apart from engraftment efficacy, tolerability towards certain cytostatic drugs… read more here.
Keywords: medicine; nsg mice; precision medicine; pdx models ... See more keywords
Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors
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DOI: 10.1093/annonc/mdx416
Abstract: Background While patient-derived xenografts (PDXs) offer a powerful modality for translational cancer research, a precise evaluation of how accurately patient responses correlate with matching PDXs in a large, heterogeneous population is needed for assessing the… read more here.
Keywords: solid tumors; pdx models; derived xenografts; cancer ... See more keywords
DIPG-42. TOWARD MULTIMODALITY THERAPY FOR DIPG/DMG: DEVELOPMENT AND INVESTIGATION OF CRANIOSPINAL IRRADIATION AND CONVECTION-ENHANCED DELIVERY PDX MODELS
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DOI: 10.1093/neuonc/noaa222.089
Abstract: Abstract BACKGROUND Diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG) are metastatic diseases, as demonstrated by early convection-enhanced delivery (CED) clinical trials in which prolonged local tumor control can sometimes be achieved, but… read more here.
Keywords: pdx models; delivery; convection enhanced; dipg ... See more keywords
Generation and application of patient-derived xenograft models in pancreatic cancer research
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DOI: 10.1097/cm9.0000000000000524
Abstract: Abstract Objective: Pancreatic ductal adenocarcinoma cancer (PDAC) is one of the leading causes of cancer-related death worldwide. Hence, the development of effective anti-PDAC therapies is urgently required. Patient-derived xenograft (PDX) models are useful models for… read more here.
Keywords: pdx models; cancer; derived xenograft; patient derived ... See more keywords
Report of the use of patient‐derived xenograft models in the development of anticancer drugs in Japan
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DOI: 10.1111/cas.14564
Abstract: Abstract Cell line‐derived xenograft (CDX) models created by implanting cancer cell lines into immunodeficient mice have contributed largely to the development of cancer drug therapies. However, cell lines often lose their original biological characteristics through… read more here.
Keywords: pdx models; development anticancer; derived xenograft; anticancer drugs ... See more keywords
Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance
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DOI: 10.1126/sciadv.abq4617
Abstract: Chemotherapy resistance and relapses are common in high-risk neuroblastoma (NB), an aggressive pediatric solid tumor of the sympathetic nervous system. Here, we developed a clinically-relevant in vivo treatment protocol mimicking the first line five-chemotherapy treatment… read more here.
Keywords: clinically relevant; resistance; treatment; pdx models ... See more keywords
Immune cell infiltration pattern in non-small cell lung cancer PDX models is a model immanent feature and correlates with a distinct molecular and phenotypic make-up
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DOI: 10.1136/jitc-2021-004412
Abstract: Background The field of cancer immunology is rapidly moving towards innovative therapeutic strategies, resulting in the need for robust and predictive preclinical platforms reflecting the immunological response to cancer. Well characterized preclinical models are essential… read more here.
Keywords: oncology; cell; non small; pdx models ... See more keywords
Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations
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DOI: 10.1158/1078-0432.ccr-16-3250
Abstract: Purpose: To evaluate the antitumor efficacy of cetuximab in combination with LSN3074753, an analog of LY3009120 and pan-RAF inhibitor in 79 colorectal cancer patient-derived xenograft (PDX) models. Experimental Design: Seventy-nine well-characterized colorectal cancer PDX models… read more here.
Keywords: trial; pdx models; raf; colorectal cancer ... See more keywords
Abstract A008: Establishment of novel gastric cancer PDX models and cell lines for developing new therapeutics
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DOI: 10.1158/1535-7163.targ-17-a008
Abstract: It is essential to have appropriate preclinical models for developing new drugs for gastric cancer (GC). Cell lines have been the most commonly used model for this purpose. However, the numbers of gastric cancer cell… read more here.
Keywords: developing new; pdx models; gastric cancer; cell lines ... See more keywords