Ca2+ functions as a molecular switch that controls the mutually exclusive complex formation of pyridoxal phosphatase with CIB1 or calmodulin
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13795
Abstract: Pyridoxal 5′‐phosphate (PLP) is an essential cofactor for neurotransmitter metabolism. Pyridoxal phosphatase (PDXP) deficiency in mice increases PLP and γ‐aminobutyric acid levels in the brain, yet how PDXP is regulated is unclear. Here, we identify… read more here.
Keywords: phosphatase; mutually exclusive; pdxp; pyridoxal phosphatase ... See more keywords
7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.7554/elife.93094
Abstract: Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation improves cognition… read more here.
Keywords: pdxp; vitamin; inhibitor; phosphatase ... See more keywords