Comparison of SynCAM1/CADM1 PDZ interactions with MUPP1 using mammalian and bacterial pull‐down systems
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1587
Abstract: Synaptic cell adhesion molecule 1 (SynCAM1) also known as cell adhesion molecule 1 (CADM1) is a transmembrane cell adhesion protein that operates in a variety of physiological and pathological cellular contexts, and its interaction with… read more here.
Keywords: comparison syncam1; syncam1 cadm1; cadm1 pdz; cell adhesion ... See more keywords
Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4396
Abstract: PDZ domains are the most diffused protein–protein interaction modules of the human proteome and are often present in tandem repeats. An example is PDZD2, a protein characterized by the presence of six PDZ domains that… read more here.
Keywords: folding intermediate; pdz; pdz domains; binding properties ... See more keywords
Dynamic Control of Signaling by Phosphorylation of PDZ Binding Motifs.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1166-1_11
Abstract: The dynamic regulation of protein-protein interactions (PPIs) involves phosphorylation of short liner motifs in disordered protein regions modulating binding affinities. The ribosomal-S6-kinase 1 is capable of binding to scaffold proteins containing PDZ domains through a… read more here.
Keywords: control signaling; dynamic control; pdz; pdz binding ... See more keywords
Identification of PDZ Interactions by Affinity Purification and Mass Spectrometry Analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1166-1_2
Abstract: Identification of protein networks becomes indispensable for determining the function of a given protein of interest. Some proteins harbor a PDZ binding motif (PDZBM) located at the carboxy-terminus end. This motif is necessary to recruit… read more here.
Keywords: spectrometry analysis; pdz interactions; mass spectrometry; pdz ... See more keywords
Identification of PDZ Interactions by Proteomic Peptide Phage Display.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1166-1_3
Abstract: PSD95-Disc large-Zonula occludens (PDZ) domains are among the most abundant modular domains in the human proteome. They typically bind short carboxy-terminal sequence motifs of their ligand proteins, which may be transmembrane proteins such as ion… read more here.
Keywords: identification; peptide phage; pdz; phage display ... See more keywords
Gβγ recruits and activates P-Rex1 via two independent binding interfaces.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.12.089
Abstract: Gβγ marks the inner side of the plasma membrane where chemotactic GPCRs activate Rac to lead the assembly of actin filaments that push the cell to move forward. Upon dissociation from heterotrimeric Gi, Gβγ recruits… read more here.
Keywords: recruits activates; rex1; rex1 via; activates rex1 ... See more keywords
Two barcodes encoded by the type-1 PDZ and by phospho-Ser312 regulate retromer/WASH-mediated sorting of the ß1-adrenergic receptor from endosomes to the plasma membrane.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2016.10.014
Abstract: Recycling of the majority of agonist-internalized GPCR is dependent on a type I-PDZ "barcode" in their C-tail. The recycling of wild-type (WT) ß1-AR is also dependent on its default "type-1 PDZ barcode", but trafficking of… read more here.
Keywords: ser312; type pdz; phospho ser312; pdz ... See more keywords
Downregulation of PDZ Domain Containing 1 (PDZK1) is a Poor Prognostic Marker for Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.01.012
Abstract: Article history: Received 9 January 2017 Accepted 9 January 2017 Available online 12 January 2017 jacent tissue from the same patient. Furthermore, immunohistochemical analyses showed low PDZK1 protein expression was correlated with a shorter overall… read more here.
Keywords: domain containing; downregulation pdz; january 2017; pdz ... See more keywords
PDZ Ligand Binding-Induced Conformational Coupling of the PDZ-SH3-GK Tandems in PSD-95 Family MAGUKs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.11.003
Abstract: Discs large (DLG) MAGUKs are abundantly expressed in glutamatergic synapses, crucial for synaptic transmission, and plasticity by anchoring various postsynaptic components including glutamate receptors, downstream scaffold proteins and signaling enzymes. Different DLG members have shared… read more here.
Keywords: pdz; binding induced; conformational coupling; ligand binding ... See more keywords
Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01697-9
Abstract: Peptidoglycan (PG) is a highly cross-linked, protective mesh-like sacculus that surrounds the bacterial cytoplasmic membrane. Expansion of PG is tightly coupled to growth of a bacterial cell and requires hydrolases to cleave the cross-links for… read more here.
Keywords: degradation; protease prc; pdz; pdz protease ... See more keywords
Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08193-6
Abstract: Human protein tyrosine phosphatase non-receptor type 4 (PTPN4) has been shown to prevent cell death. The active form of human PTPN4 consists of two globular domains, a PDZ (PSD-95/Dlg/ZO-1) domain and a phosphatase domain, tethered… read more here.
Keywords: ptpn4; phosphatase; pdz; linker ... See more keywords