Dynamic Control of Signaling by Phosphorylation of PDZ Binding Motifs.
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DOI: 10.1007/978-1-0716-1166-1_11
Abstract: The dynamic regulation of protein-protein interactions (PPIs) involves phosphorylation of short liner motifs in disordered protein regions modulating binding affinities. The ribosomal-S6-kinase 1 is capable of binding to scaffold proteins containing PDZ domains through a… read more here.
Keywords: control signaling; dynamic control; pdz; pdz binding ... See more keywords
PDZ-binding kinase inhibitor OTS514 suppresses the proliferation of oral squamous carcinoma cells.
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DOI: 10.1111/odi.14533
Abstract: OBJECTIVE PDZ-binding kinase (PBK) has been reported as a poor prognostic factor and is a promising molecular target for anti-cancer therapeutics. Here, we aimed to investigate the effect of specific PBK inhibitor OTS514 on the… read more here.
Keywords: oscc cells; pdz binding; ots514; inhibitor ots514 ... See more keywords
PDZ Binding Kinase/T-LAK Cell-Derived Protein Kinase Plays an Oncogenic Role and Promotes Immune Escape in Human Tumors
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DOI: 10.1155/2021/8892479
Abstract: Background PDZ binding kinase (PBK)/T-LAK cell-derived protein kinase (TOPK) is an important mitotic kinase that promotes tumor progression in some cancers. However, the pan-cancer analysis of PBK/TOPK and its role in tumor immunity are limited.… read more here.
Keywords: kinase; role; pdz binding; pbk ... See more keywords
Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice
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DOI: 10.1210/js.2017-00338
Abstract: Abstract The proliferation of pancreatic β cells is enhanced to enable an increase in β-cell mass and to compensate for insulin resistance during pregnancy. To elucidate the mechanisms involved, we previously investigated islets from pregnant… read more here.
Keywords: binding kinase; kinase; expression; pdz binding ... See more keywords
Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein
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DOI: 10.18632/oncotarget.14469
Abstract: The function of a conserved PDS95/DLG1/ZO1 (PDZ) binding motif (E6 PBM) at the C-termini of E6 oncoproteins of high-risk human papillomavirus (HPV) types contributes to the development of HPV-associated malignancies. Here, using a primary human… read more here.
Keywords: genome containing; binding motif; human papillomavirus; genome ... See more keywords
Yes-Associated Protein and Transcriptional Coactivator with PDZ-Binding Motif in Cardiovascular Diseases
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DOI: 10.3390/ijms24021666
Abstract: Yes-associated protein (YAP, also known as YAP1) and its paralogue TAZ (with a PDZ-binding motif) are transcriptional coactivators that switch between the cytoplasm and nucleus and regulate the organ size and tissue homeostasis. This review… read more here.
Keywords: pdz binding; binding motif; yes associated; cardiovascular diseases ... See more keywords