Downregulation of PDZ Domain Containing 1 (PDZK1) is a Poor Prognostic Marker for Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.01.012
Abstract: Article history: Received 9 January 2017 Accepted 9 January 2017 Available online 12 January 2017 jacent tissue from the same patient. Furthermore, immunohistochemical analyses showed low PDZK1 protein expression was correlated with a shorter overall… read more here.
Keywords: domain containing; downregulation pdz; january 2017; pdz ... See more keywords
Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01569
Abstract: The rapid identification of early hits by fragment-based approaches and subsequent hit-to-lead optimization represents a challenge for drug discovery. To address this challenge, we created a strategy called "DOTS" that combines molecular dynamic simulations, computer-based… read more here.
Keywords: chemistry; identification; optimization; pdz domain ... See more keywords
Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12827-0
Abstract: PDZ domains are one of the most important protein-protein interaction domains in human. While presenting a conserved three dimensional structure, a substantial number of PDZ domains display structural extensions suggested to be involved in their… read more here.
Keywords: third pdz; domain psd; pdz; extension ... See more keywords
Tight junction formation by a claudin mutant lacking the COOH‐terminal PDZ domain‐binding motif
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14881
Abstract: Claudin‐based tight junctions (TJs) are formed at the most apical part of cell–cell contacts in epithelial cells. Previous studies suggest that scaffolding proteins ZO‐1 and ZO‐2 (ZO proteins) determine the location of TJs by interacting… read more here.
Keywords: pdz domain; binding motif; terminal pdz; domain binding ... See more keywords
Compound heterozygous variants in the multiple PDZ domain protein (MPDZ) cause a case of mild non-progressive communicating hydrocephalus
Sign Up to like & getrecommendations! Published in 2018 at "BMC Medical Genetics"
DOI: 10.1186/s12881-018-0540-x
Abstract: BackgroundCongenital hydrocephalus (CH) results from the accumulation of excessive amounts of cerebrospinal fluid (CSF) in the brain, often leading to severe neurological impairments. However, the adverse effects of CH can be reduced if the condition… read more here.
Keywords: heterozygous variants; multiple pdz; compound heterozygous; gene ... See more keywords
Selective function of the PDZ domain of Dishevelled in noncanonical Wnt signalling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.259547
Abstract: ABSTRACT Dishevelled is a cytoplasmic hub that transduces Wnt signals to cytoplasmic effectors, which can be broadly characterised as canonical (β-catenin dependent) and noncanonical, to specify cell fates and behaviours during development. To transduce canonical… read more here.
Keywords: noncanonical wnt; domain; pdz domain; polarity ... See more keywords
GIPC3 couples to MYO6 and PDZ domain proteins, and shapes the hair cell apical region
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cell Science"
DOI: 10.1242/jcs.261100
Abstract: ABSTRACT GIPC3 has been implicated in auditory function. Here, we establish that GIPC3 is initially localized to the cytoplasm of inner and outer hair cells of the cochlea and then is increasingly concentrated in cuticular… read more here.
Keywords: cell; pdz domain; hair cells; hair ... See more keywords
Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Systems Biology"
DOI: 10.15252/msb.20178129
Abstract: A key function of reversible protein phosphorylation is to regulate protein–protein interactions, many of which involve short linear motifs (3–12 amino acids). Motif‐based interactions are difficult to capture because of their often low‐to‐moderate affinities. Here,… read more here.
Keywords: motif based; phospho; domain interactions; phosphorylation ... See more keywords
Residue-Level Contact Reveals Modular Domain Interactions of PICK1 Are Driven by Both Electrostatic and Hydrophobic Forces
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.616135
Abstract: PICK1 is a multi-domain scaffolding protein that is uniquely comprised of both a PDZ domain and a BAR domain. While previous experiments have shown that the PDZ domain and the linker positively regulate the BAR… read more here.
Keywords: pdz domain; hydrophobic forces; electrostatic hydrophobic; bar ... See more keywords
Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1192621
Abstract: The human protein tyrosine phosphatase non-receptor type 3 (PTPN3) is a phosphatase containing a PDZ (PSD-95/Dlg/ZO-1) domain that has been found to play both tumor-suppressive and tumor-promoting roles in various cancers, despite limited knowledge of… read more here.
Keywords: pdz; phosphatase; pdz domain; ptpn3 pdz ... See more keywords
Endosomal Sorting Protein SNX27 and Its Emerging Roles in Human Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers15010070
Abstract: Simple Summary The sorting nexin (SNX) family of proteins mediate the sorting and trafficking of endocytosed transmembrane proteins between the endosomal compartments, lysosome, trans-Golgi network, and plasma membrane. SNXs are characterized by the presence of… read more here.
Keywords: pdz domain; snx27; sorting protein; domain ... See more keywords