Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat
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DOI: 10.1002/pro.4396
Abstract: PDZ domains are the most diffused protein–protein interaction modules of the human proteome and are often present in tandem repeats. An example is PDZD2, a protein characterized by the presence of six PDZ domains that… read more here.
Keywords: folding intermediate; pdz; pdz domains; binding properties ... See more keywords
Site-Specific Phosphorylation of PDZ Domains.
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DOI: 10.1007/978-1-0716-0434-2_12
Abstract: Classical approaches for probing protein phosphorylation events rely on phosphomimicking amino acids or enzymatic phosphorylation of proteins. In many cases, phosphomimicking amino acids inadequately imitate actual protein phosphorylation, whereas the latter method suffers from an… read more here.
Keywords: site specific; pdz domains; phosphorylation; amino acids ... See more keywords
Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95
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DOI: 10.1038/s41467-018-06133-0
Abstract: Previous studies of the N-terminal PDZ tandem from PSD-95 produced divergent models and failed to identify interdomain contacts stabilizing the structure. We used ensemble and single-molecule FRET along with replica-exchange molecular dynamics to fully characterize… read more here.
Keywords: domains psd; interdomain interactions; pdz domains; interdomain ... See more keywords
Deciphering the Molecular Interaction Between the Adhesion G Protein-Coupled Receptor ADGRV1 and its PDZ-Containing Regulator PDZD7
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DOI: 10.3389/fmolb.2022.923740
Abstract: Hearing relies on the transduction of sound-evoked vibrations into electrical signals, occurring in the stereocilia bundle of inner ear hair cells. The G protein-coupled receptor (GPCR) ADGRV1 and the multi-PDZ protein PDZD7 play a critical… read more here.
Keywords: coupled receptor; pdz; adgrv1 pdz; pdz domains ... See more keywords
Ensemble-Based Analysis of the Dynamic Allostery in the PSD-95 PDZ3 Domain in Relation to the General Variability of PDZ Structures
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DOI: 10.3390/ijms21218348
Abstract: PDZ domains are abundant interaction hubs found in a number of different proteins and they exhibit characteristic differences in their structure and ligand specificity. Their internal dynamics have been proposed to contribute to their biological… read more here.
Keywords: upon ligand; ligand binding; pdz domains; pdz ... See more keywords