Cyclic band compression in toroidal capillary electrophoresis delivers an unlimited number of theoretical plates with a quadratic growth in time and a constant peak capacity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of separation science"
DOI: 10.1002/jssc.201800099
Abstract: Analytical instruments able to provide extremely high sensitivities, separation efficiencies, and peak capacities are important for both applied sciences and basic research. It is even more interesting if this can be achieved within organic, aqueous,… read more here.
Keywords: compression; time; toroidal capillary; number ... See more keywords
Generic Ultrahigh Resolution HPLC Methods: An Efficient Way to Tackle Singular Analytical Problems in Industrial Analytics
Sign Up to like & getrecommendations! Published in 2017 at "Chromatographia"
DOI: 10.1007/s10337-017-3300-8
Abstract: In HPLC today, separation tasks are getting more and more complex. Often very heterogeneous mixtures containing hundreds of components have to be separated. If samples have such a complexity it is not possible to separate… read more here.
Keywords: generic ultrahigh; hplc; hplc methods; resolution hplc ... See more keywords
Towards a high peak capacity of 130 using nanoflow hydrophilic interaction liquid chromatography.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2019.01.060
Abstract: Hydrophilic interaction liquid chromatography, HILIC, is a relatively new HPLC mode. Compared with other HPLC modes, HILIC is a high resolution chromatographic mode with high peak capacity for separations of complex mixtures. Although the separation… read more here.
Keywords: chromatography; high peak; interaction liquid; hydrophilic interaction ... See more keywords
Design Guidelines and Kinetic Performance Limits for Spatial Comprehensive Three-Dimensional Chromatography for the Analysis of Intact Proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01842
Abstract: The design aspects of microfluidic chips for spatial three-dimensional chromatography featuring an interconnected channel network and targeting protein analysis are discussed, and the corresponding kinetic performance limits have been established using a Pareto-optimality approach. The… read more here.
Keywords: dimensional chromatography; performance limits; three dimensional; analysis ... See more keywords
Surface-Charged Hybrid Monolithic Column for MS-Compatible Peptide Separation with High Peak Capacity and Its Application in Proteomic Analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02084
Abstract: For bottom-up proteomics, peptide separation with high peak capacity under MS-compatible conditions is of vital significance to increase proteome coverage. Herein, a surface-charged ethane-bridged hybrid monolithic column was prepared based on the efficient ring-opening reaction… read more here.
Keywords: separation; peak capacity; hybrid monolithic; surface charged ... See more keywords
Achieving a peak capacity of 1800 using an 8 m long pillar array column.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b02236
Abstract: In the present study, the peak capacity potential of ultra-long porous cylindrical pillar array columns is investigated. Coupling 4 columns of 2 m long allows to work near the minimal separation impedance of small molecules… read more here.
Keywords: achieving peak; pillar array; peak capacity; capacity ... See more keywords
An improved nanoflow RPLC-CZE-MS/MS system with high peak capacity and sensitivity for nanogram bottom-up proteomics.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00545
Abstract: Novel mass spectrometry (MS)-based proteomic tools with extremely high sensitivity and high peak capacity are required for comprehensive characterization of protein molecules in mass-limited samples. We reported a nanoRPLC-CZE-MS/MS system for deep bottom-up proteomics of… read more here.
Keywords: cze system; system; cze; sensitivity ... See more keywords
A high-throughput and high peak capacity narrow-bore parallel segmented flow column strategy for the liquid chromatography-tandem mass spectrometry analysis of organic contaminants in water
Sign Up to like & getrecommendations! Published in 2020 at "Analytical Methods"
DOI: 10.1039/c9ay02370d
Abstract: This study highlights the development of a high peak capacity, high-throughput (HTP) approach for a target list of 62 organic contaminants in an environmental river water matrix on a HPLC conventional 400 bar system. Key… read more here.
Keywords: column; water; analysis; peak ... See more keywords