PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-021-00761-5
Abstract: Pseudopodium-enriched atypical kinase 1 (PEAK1) has been reported to be upregulated in human malignancies and is correlated with a poor prognosis. Enhanced PEAK1 expression facilitates tumor cell survival, invasion, metastasis and chemoresistance. However, the role… read more here.
Keywords: breast; peak1; breast cancer; metastasis ... See more keywords
Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription
Sign Up to like & getrecommendations! Published in 2018 at "Cell Discovery"
DOI: 10.1038/s41421-018-0024-3
Abstract: PEAK1 is a newly described tyrosine kinase and scaffold protein that transmits integrin-mediated extracellular matrix (ECM) signals to facilitate cell movement and growth. While aberrant expression of PEAK1 has been linked to cancer progression, its… read more here.
Keywords: transcription; peak1; kinase; vessel formation ... See more keywords