Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2018024950
Abstract: Fucoidans are sulfated fucose-based polysaccharides that activate platelets and have pro- and anticoagulant effects; thus, they may have therapeutic value. In the present study, we show that 2 synthetic sulfated α-l-fucoside-pendant glycopolymers (with average monomeric… read more here.
Keywords: aggregation; synthetic glycopolymers; glycopolymers natural; pear1 ... See more keywords
Association of colorectal cancer with genetic and epigenetic variation in PEAR1—A population-based cohort study
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DOI: 10.1371/journal.pone.0266481
Abstract: Platelet Endothelial Aggregation Receptor 1 (PEAR1) modulates angiogenesis and platelet contact-induced activation, which play a role in the pathogenesis of colorectal cancer. We therefore tested the association of incident colorectal cancer and genetic and epigenetic… read more here.
Keywords: pear1; cancer; methylation; cancer genetic ... See more keywords
Variants of PEAR1 Are Associated With Outcome in Patients With ACS and Stable CAD Undergoing PCI
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00490
Abstract: Introduction: Platelet endothelial aggregation receptor 1 (PEAR1) triggers platelet aggregation and is expressed in platelets and endothelial cells. Genome-wide association studies (GWAS) showed an association between platelet function and single-nucleotide polymorphisms (SNPs) in PEAR1. Methods:… read more here.
Keywords: undergoing pci; hazard ratio; pear1 associated; cad ... See more keywords