Antagonism Between PEDF and TGF‐β Contributes to Type VI Osteogenesis Imperfecta Bone and Vascular Pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4540
Abstract: Osteogenesis imperfecta (OI) is a heterogeneous genetic disorder of bone and connective tissue, also known as brittle bone disease. Null mutations in SERPINF1, which encodes pigment epithelium‐derived factor (PEDF), cause severe type VI OI, characterized… read more here.
Keywords: pedf; bone; osteogenesis; type ... See more keywords
The pigment epithelium-derived factor (PEDF): an important potential therapeutic agent for infantile hemangioma
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-017-1716-5
Abstract: In previous studies, the expression and the role of proangiogenic factors in infantile hemangiomas have been well studied. However, the role of angiogenic inhibitors has been revealed rarely. The expression of PEDF, as the strongest… read more here.
Keywords: expression pedf; infantile hemangioma; pedf; hemangioma ... See more keywords
Pigment epithelium‐derived factor improves TNF&agr;‐induced hepatic steatosis in grass carp (Ctenopharyngodon idella)
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2017.01.016
Abstract: ABSTRACT Pro‐inflammatory cytokines, such as tumor necrosis factor alpha (TNF&agr;), may contribute to hepatic steatosis in the situation of excess lipid accumulation in farmed fish. Pigment epithelium‐derived factor (PEDF) is an endogenous anti‐inflammatory factor and… read more here.
Keywords: hepatic steatosis; agr; tnf agr; grass carp ... See more keywords
Pigment epithelium-derived factor (PEDF) ameliorates arsenic-induced vascular endothelial dysfunction in rats and toxicity in endothelial EA.hy926 cells.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental research"
DOI: 10.1016/j.envres.2020.109506
Abstract: Although the harmful effects of arsenic exposure on the cardiovascular system have received great attention, there is still no effective treatment. Vascular endothelial dysfunction (VED) is the initial step of cardiovascular diseases, where pigment epithelium-derived… read more here.
Keywords: vascular endothelial; exposure; pedf; pigment epithelium ... See more keywords
PEDF plus DHA modulate inflammation and stimulate nerve regeneration after HSV‐1 infection
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.06.015
Abstract: ABSTRACT Herpes simplex virus type‐1 (HSV‐1) infection leads to impaired corneal sensation and, in severe cases, to corneal ulceration, melting and perforation. Here, we explore the potential therapeutic action of pigment epithelial‐derived factor (PEDF) plus… read more here.
Keywords: hsv infection; treatment; dha; pedf ... See more keywords
Novel anti-angiogenic PEDF-Derived small peptides mitigate, choroidal neovascularization.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107798
Abstract: Abnormal migration and proliferation of endothelial cells (EC) drive neovascular retinopathies. While anti-VEGF treatment slows progression, pathology is often supported by decrease in intraocular pigment epithelium-derived factor (PEDF), an endogenous inhibitor of angiogenesis. A surface… read more here.
Keywords: choroidal neovascularization; mer; angiogenic pedf; pedf ... See more keywords
Pigment epithelium derived factor play a positive role in bone mineralization of osteoblasts derived from diabetic patients.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2017.07.018
Abstract: Pigment epithelium-derived factor (PEDF) is a multifunctional secreted protein which plays important role in anti-angiogenic, anti-tumorigenic, as well as involves in the metabolism and regeneration of bone. In this study, our aim is to investigate… read more here.
Keywords: pedf; diabetic patients; bone; role ... See more keywords
PEDF increases GLUT4-mediated glucose uptake in rat ischemic myocardium via PI3K/AKT pathway in a PEDFR-dependent manner.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.02.035
Abstract: BACKGROUND Targeted increase in glucose uptake of ischemic myocardium is a potential therapeutic strategy for myocardial ischemia. PEDF presents a profound moderating effect on glucose metabolism of cells, but its role is still controversial. Here,… read more here.
Keywords: uptake ischemic; pedf; glucose uptake; ischemic myocardium ... See more keywords
Microstructure dependent binding of pigment epithelium derived factor (PEDF) to type I collagen fibrils.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2017.06.001
Abstract: Pigment epithelium derived factor (PEDF) is a multifunctional extracellular protein. In addition to its known anti-angiogenic and neurotrophic roles in collagen rich tissues, PEDF is thought to be involved in collagen fibril assembly due to… read more here.
Keywords: collagen; collagen fibrils; epithelium derived; pedf ... See more keywords
Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2016.09.036
Abstract: Pigment epithelium-derived factor (PEDF) expression is downregulated in the kidneys of diabetic rats, and delivery of PEDF suppressed renal fibrotic factors in these animals. PEDF has multiple functions including anti-angiogenic, anti-inflammatory and antifibrotic activities. Since… read more here.
Keywords: tubule epithelial; epithelium derived; pedf; pigment epithelium ... See more keywords
Pigment epithelium-derived factor attenuates myocardial fibrosis via inhibiting Endothelial-to-Mesenchymal Transition in rats with acute myocardial infarction
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41932
Abstract: Endothelial mesenchymal transition (EndMT) plays a critical role in the pathogenesis and progression of interstitial and perivascular fibrosis after acute myocardial infarction (AMI). Pigment epithelium-derived factor (PEDF) is shown to be a new therapeutic target… read more here.
Keywords: mesenchymal transition; fibrosis; endothelial mesenchymal; catenin ... See more keywords