Clinical characteristics and prognosis analysis of patients with de novo ASXL1-mutated AML treated with the C-HUNAN-AML-15 protocol: A multicenter study by the South China Pediatric AML Collaborative Group.
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DOI: 10.1002/cam4.6005
Abstract: BACKGROUND ASXL1 mutation is an independent prognostic factor in adult acute myeloid leukemia (AML), but its effect on the prognosis of pediatric AML is poorly understood. AIMS This study aimed to investigate the clinical characteristics… read more here.
Keywords: prognosis; aml; group; south china ... See more keywords
Silencing of lncRNA UCA1 curbs proliferation and accelerates apoptosis by repressing SIRT1 signals by targeting miR‐204 in pediatric AML
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22435
Abstract: The long noncoding RNA urothelial carcinoma‐associated 1 (UCA1) has been reported to sustain the proliferation of acute myeloid leukemia (AML) cells through downregulating cell cycle regulators p27kip1. Yet, the foundational mechanism of UCA1 in AML… read more here.
Keywords: mir 204; pediatric aml; expression; proliferation ... See more keywords
Distinct prognostic values of Annexin family members expression in acute myeloid leukemia
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DOI: 10.1007/s12094-019-02045-7
Abstract: BackgroundAnnexin family consist of 12 members, many of them are frequently dysregulated in human cancers. However, the diagnosis and prognosis of Annexin family expression in acute myeloid leukemia (AML) remain elusive. The aim of the… read more here.
Keywords: aml patients; pediatric aml; family members; annexin family ... See more keywords
Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004
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DOI: 10.1038/leu.2017.121
Abstract: We conducted a cytogenetic analysis of 642 children with de novo acute myeloid leukemia (AML) treated on the AML-Berlin-Frankfurt-Münster (BFM) 04 protocol to determine the prognostic value of specific chromosomal aberrations including monosomal (MK+), complex… read more here.
Keywords: pediatric aml; monosomal karyotype; outcome; bfm ... See more keywords
Regulatory Networks of Prognostic mRNAs in Pediatric Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Healthcare Engineering"
DOI: 10.1155/2022/2691997
Abstract: Acute myeloid leukemia (AML) in children refers to a malignant tumor caused by the abnormal proliferation of immature myeloid cells in the bone marrow and peripheral blood. The prognosis of patients with pediatric acute myeloid… read more here.
Keywords: myeloid; acute myeloid; pediatric aml; myeloid leukemia ... See more keywords
Integrated Genome Wide Association Study (GWAS) Identifies SNPs Associated with Outcome in Pediatric AML
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DOI: 10.1182/blood-2018-99-120367
Abstract: Acute myeloid leukemia (AML) treatment response remains poorly understood. Although multiple studies have focused on understanding the transcriptomic and epigenetic landscape of AML, a genome-wide analysis of SNPs in pediatric AML has not yet been… read more here.
Keywords: genome wide; significantly associated; snps; pediatric aml ... See more keywords
Genomic and Transcriptomic Characterization of Adult and Pediatric Relapsed Acute Myeloid Leukemia Reveals Novel Therapeutic Targets
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DOI: 10.1182/blood-2020-139427
Abstract: Acute myeloid leukemia (AML) is the overall most common form of acute leukemia, characterized by a high relapse frequency and low long-term survival rate especially for adults. Even though children with AML have a better… read more here.
Keywords: pediatric aml; relapse; adult pediatric; aml ... See more keywords
Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2019000404
Abstract: Recent advances in the genetic understanding of acute myeloid leukemia (AML) have improved clinical outcomes in pediatric patients. However, ∼40% of patients with pediatric AML relapse, resulting in a relatively low overall survival rate of… read more here.
Keywords: myeloid leukemia; pediatric aml; genetic background; acute myeloid ... See more keywords
Distinct signaling events promote resistance to mitoxantrone and etoposide in pediatric AML: a Children’s Oncology Group report
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DOI: 10.18632/oncotarget.21363
Abstract: Despite aggressive chemotherapy including mitoxantrone and etoposide, relapse occurs for almost half of children with acute myeloid leukemia (AML). Since both drugs inhibit topoisomerase II and cause DNA double strand breaks, resistance could be achieved… read more here.
Keywords: pediatric aml; stroma; resistance; mitoxantrone etoposide ... See more keywords
Clinical Grade Production of Wilms’ Tumor-1 Loaded Cord Blood-Derived Dendritic Cells to Prevent Relapse in Pediatric AML After Cord Blood Transplantation
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DOI: 10.3389/fimmu.2020.559152
Abstract: Hematopoietic cell transplantation (HCT) is a last resort, potentially curative treatment option for pediatric patients with refractory acute myeloid leukemia (AML). Cord blood transplantation (CBT) results in less relapses and less graft-versus-host disease when compared… read more here.
Keywords: cord; pediatric aml; transplantation; cord blood ... See more keywords
Proteomic Profiling Identifies Specific Leukemic Stem Cell-Associated Protein Expression Patterns in Pediatric AML Patients
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DOI: 10.3390/cancers14153567
Abstract: Simple Summary Acute myeloid leukemia is an aggressive cancer in children and novel therapeutic tools are warranted to improve outcomes and reduce late effects in these patients. In this study, we isolate and explore the… read more here.
Keywords: protein expression; pediatric aml; stem; leukemic stem ... See more keywords