Precision medicine for pediatric cancers lags behind that for adult cancers
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DOI: 10.1002/cncr.32685
Abstract: CancerScope A lthough scientists have made great strides in applying breakthroughs in precision medicine to many adult cancers, the same cannot be said of pediatric diseases. However, researchers, advocates, and lawmakers are hoping to bridge… read more here.
Keywords: medicine; drug; pediatric cancers; cancer ... See more keywords
Neurological Complications of Childhood Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in pediatric neurology"
DOI: 10.1016/j.spen.2016.12.005
Abstract: Though the treatment of pediatric cancers has come a long way, acute and chronic effects of cancer are still affecting the life of many children. These effects may be caused not only by the malignancy… read more here.
Keywords: complications childhood; nervous system; pediatric cancers; neurological complications ... See more keywords
Geospatial Distribution of AgeâAdjusted Incidence of the Three Major Types of Pediatric Cancers and Waterborne Agrichemicals in Nebraska
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DOI: 10.1029/2021gh000419
Abstract: This study was conducted to examine, at the county level, the relationship between pediatric cancer incidence rate and atrazine and nitrate mean concentrations in surface and groundwater. A negative binomial regression analysis was performed to… read more here.
Keywords: brain cns; pediatric cancers; age adjusted; incidence ... See more keywords
Molecular Mechanism of Telomere Length Dynamics and Its Prognostic Value in Pediatric Cancers.
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DOI: 10.1093/jnci/djz210
Abstract: BACKGROUND We aimed to systematically evaluate telomere dynamics across a spectrum of pediatric cancers, search for underlying molecular mechanisms, and assess potential prognostic value. METHODS The fraction of telomeric reads was determined from whole-genome sequencing… read more here.
Keywords: telomere fractions; prognostic value; pediatric cancers; cancer ... See more keywords
Challenges and solutions to the study of rare childhood tumors.
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DOI: 10.1097/mop.0000000000000857
Abstract: PURPOSE OF REVIEW The majority of progress made in pediatric oncology over the past 50 years has been achieved in the most common cancers. Rare pediatric cancers, which collectively comprise more than 10% of all… read more here.
Keywords: treatment rare; cancer genomics; rare pediatric; study treatment ... See more keywords
Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers
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DOI: 10.1126/sciadv.aba3064
Abstract: Joint analysis of genomic and transcriptomic data reveals diverse noncoding mutation landscapes in five types of pediatric cancers. Interpreting the function of noncoding mutations in cancer genomes remains a major challenge. Here, we developed a… read more here.
Keywords: deregulation cis; contribute deregulation; noncoding mutations; diverse noncoding ... See more keywords
The genomic landscape of pediatric cancers: Implications for diagnosis and treatment
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aaw3535
Abstract: The past decade has witnessed a major increase in our understanding of the genetic underpinnings of childhood cancer. Genomic sequencing studies have highlighted key differences between pediatric and adult cancers. Whereas many adult cancers are… read more here.
Keywords: cancers implications; implications diagnosis; diagnosis treatment; pediatric cancers ... See more keywords
Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra.
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DOI: 10.1158/0008-5472.can-16-1106
Abstract: Pediatric cancers are generally characterized by low mutational burden and few recurrently mutated genes. Recent studies suggest that genomic alterations may help guide treatment decisions and clinical trial selection. Here, we describe genomic profiles from… read more here.
Keywords: alk; pediatric cancers; set diverse; large set ... See more keywords
Abstract IA06: New strategies for multidimensional molecular characterization and follow-up of high-risk pediatric cancers
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DOI: 10.1158/1538-7445.pedca19-ia06
Abstract: Although 80% of all pediatric patients with cancer can be cured based on modern multimodal therapeutic strategies, at least 20% of these patients will undergo tumor progression or relapse. Understanding the molecular mechanisms underlying tumor… read more here.
Keywords: risk pediatric; risk; high risk; pediatric cancers ... See more keywords
B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral Immunity to Oncogenic Driver in Pediatric Cancers
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DOI: 10.1158/1541-7786.mcr-22-0567
Abstract: Abstract B-cell lymphoma 6 (BCL6) is a protooncogene in adult and pediatric cancers, first identified in diffuse large B-cell lymphoma (DLBCL) where it acts as a repressor of the tumor suppressor TP53, conferring survival, protection,… read more here.
Keywords: pediatric cancers; cell lymphoma; humoral immunity; lymphoma bcl6 ... See more keywords
Pediatric Cancers with Low Mutation Burden Can Be Immunogenic.
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DOI: 10.1158/2159-8290.cd-rw2019-103
Abstract: CD8+ tumor-infiltrating lymphocytes mount a response to neoantigens in acute lymphoblastic leukemia. read more here.
Keywords: cancers low; burden immunogenic; mutation burden; pediatric cancers ... See more keywords