Clinical Impact of Immunoglobulin Heavy Chain Clonality in Pediatric B‐Cell Precursor Acute Lymphoblastic Leukemia
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DOI: 10.1002/cam4.71336
Abstract: Recent advancements in risk stratification have greatly improved outcomes in pediatric B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). Despite favorable prognostic indicators, including the absence of cytogenetic abnormalities and minimal residual disease (MRD) negativity, relapse remains… read more here.
Keywords: cell precursor; acute lymphoblastic; lymphoblastic leukemia; precursor acute ... See more keywords
How to combine multiple tools for the genetic diagnosis work-up of pediatric B-cell acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Hematology"
DOI: 10.1007/s00277-024-06151-7
Abstract: This study investigated the importance of comprehensive genetic diagnosis in pediatric B-cell acute lymphoblastic leukemia (B-ALL). We analyzed 175 B-ALL employing karyotyping, FISH, MLPA, targeted next-generation sequencing (t-NGS), and Optical Genome Mapping (OGM). This approach… read more here.
Keywords: diagnosis; acute lymphoblastic; lymphoblastic leukemia; genetic diagnosis ... See more keywords
Clinical outcomes and prognostic factors in children with B-cell lymphoblastic lymphoma (LBL) treated according to on modified BFM-90 protocol: Experience from a Tertiary cancer care center in India.
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric hematology and oncology"
DOI: 10.1080/08880018.2021.2005725
Abstract: Pediatric B-cell lymphoblastic lymphoma (LBL) is a rare entity, and appropriate treatment for pediatric B-cell LBL is not well defined. While intensive ALL type regimens achieve long term survival of 90% across Western co-operative group… read more here.
Keywords: protocol; cell lymphoblastic; bfm protocol; pediatric cell ... See more keywords
Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia.
Sign Up to like & getrecommendations! Published in 2023 at "Pediatric hematology and oncology"
DOI: 10.1080/08880018.2023.2201302
Abstract: Germline genetic variants influence development of pediatric B cell acute lymphoblastic leukemia (B-ALL). Genome-wide association studies (GWAS) have identified several pediatric B-ALL susceptibility loci. IKZF1 and PAX5, transcription factors involved in B cell development, have… read more here.
Keywords: cell; pediatric cell; development; tcf3 ... See more keywords
Perspectives of Fc engineered antibodies in CD19 targeting immunotherapies in pediatric B-cell precursor acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Oncoimmunology"
DOI: 10.1080/2162402x.2018.1448331
Abstract: ABSTRACT CD19 immunotherapies based on T cells opened new avenues in the treatment of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, Fc engineered CD19 antibodies may also bear great potential. In light of recent… read more here.
Keywords: precursor acute; lymphoblastic leukemia; cell precursor; acute lymphoblastic ... See more keywords
Abstract 3551: Single-cell characterization of pediatric T-cell acute lymphoblastic leukemia transcriptomes
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3551
Abstract: Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a rare cancer with a diverse set of causative genomic abnormalities. The variety and limited characterization of genomic mechanisms underlying this disease presents a unique challenge for the… read more here.
Keywords: cell; pediatric cell; single cell; acute lymphoblastic ... See more keywords
Cuplike nuclear morphology in pediatric B-cell acute lymphoblastic leukemia.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-05-848788
Abstract: ![Figure][1] A 7-year-old previously healthy girl presented with fever, fatigue, and weight loss for 1 month. Laboratory test revealed normocytic anemia (hemoglobin, 7.1 g/dL), neutropenia (0.17 × 109/L), and 30% small- to medium-sized blasts with… read more here.
Keywords: cell acute; cuplike nuclear; cuplike; morphology pediatric ... See more keywords
Clinical Impacts of Copy Number Variations in B-cell Differentiation and Cell Cycle Control Genes in Pediatric B-cell Acute Lymphoblastic Leukemia: a Single Centre Experience
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DOI: 10.2478/raon-2021-0050
Abstract: Abstract Background IKZF1 gene deletions have been identified as a poor prognostic factor in pediatric B-cell acute lymphoblastic leukemia (B-ALL), especially in the presence of co-occurring deletions (IKZF1plus profile). This study aimed to determine the… read more here.
Keywords: cell acute; number variations; cell; pediatric cell ... See more keywords
NFATc1 and NFATc2 regulate glucocorticoid resistance in pediatric T-cell acute lymphoblastic leukemia through modulation of cholesterol biosynthesis and the WNT/β-catenin pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Haematologica"
DOI: 10.3324/haematol.2025.287651
Abstract: The glucocorticoid (GC) resistance onset in pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL) patients remains one of the biggest challenges in current cancer treatment. The mechanisms driving this resistance are still not fully understood, making it… read more here.
Keywords: nfatc1 nfatc2; resistance; glucocorticoid resistance; leukemia ... See more keywords
Pediatric B cell repertoires are enriched for naive clonal phenotypes and are shaped by distinct selection dynamics
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1618234
Abstract: B cell development in early life sets the stage for how the adaptive immune system will function. Although little is known about B cell biology in children, especially from tissue-residing B cells, it has been… read more here.
Keywords: repertoires enriched; cell repertoires; mutated clones; cell ... See more keywords
Case Report: Whole genome sequencing identifies CCDC88C as a novel JAK2 fusion partner in pediatric T-cell acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.1082986
Abstract: In the present report, we applied whole genome sequencing (WGS) to genetically characterize a case of pediatric T-cell acute lymphoblastic leukemia (ALL) refractory to standard therapy. WGS identified a novel JAK2 fusion, with CCDC88C as… read more here.
Keywords: fusion; genome sequencing; pediatric cell; partner ... See more keywords