Articles with "pediatric cns" as a keyword



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The oncogenic fusion landscape in pediatric CNS neoplasms

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Published in 2022 at "Acta Neuropathologica"

DOI: 10.1007/s00401-022-02405-8

Abstract: Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-related deaths in children. Recent developments in molecular analyses have greatly contributed to a more accurate diagnosis and risk stratification of CNS… read more here.

Keywords: fusion; cns; pediatric cns; cns neoplasms ... See more keywords
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Review of the genomic landscape of common pediatric CNS tumors and how data sharing will continue to shape this landscape in the future.

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Published in 2021 at "Molecular biology reports"

DOI: 10.1007/s11033-021-06811-1

Abstract: Over the past decade we have witnessed a rapid increase in our understanding of the molecular characteristics of pediatric central nervous system (CNS) tumors. Studies that utilize genomic sequencing have revealed a heterogeneous group of… read more here.

Keywords: data sharing; cns; landscape; cns tumors ... See more keywords
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EXTH-16. TREATMENT OF THREE DIFFERENT BRAF-V600E POSITIVE BRAIN TUMORS WITH VEMURAFENIB AND DABRAFENIB/TRAMETINIB: A CASE SERIES

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Published in 2020 at "Neuro-oncology"

DOI: 10.1093/neuonc/noaa215.370

Abstract: The BRAF-V600E gene is a protein kinase involved in regulation of the mitogen activated protein kinase pathway (MAPK/MEK) and downstream extracellular receptor kinase (ERK). The BRAF-V600E mutation has a significant role in the progression of… read more here.

Keywords: braf v600e; braf; cns; pediatric cns ... See more keywords
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EPID-12. TEMPORAL AND GLOBAL GEOGRAPHIC VARIATION IN THE INCIDENCE OF PEDIATRIC CNS TUMORS, 1998–2012

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Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.198

Abstract: Abstract AIMS To describe the temporal and geographic variation in the incidence of pediatric CNS malignancies worldwide, presenting analyses by sex, period, region, and histological subtype between 1998 and 2012. METHODS Data were extracted from… read more here.

Keywords: incidence; incidence pediatric; variation; geographic variation ... See more keywords
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PATH-31. THE IMPACT OF MOLECULAR PROFILING OF PEDIATRIC CNS TUMORS ON TUMOR DIAGNOSIS AND MANAGEMENT - A SINGLE CENTER EXPERIENCE

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Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.666

Abstract: Abstract BACKGROUND Next generation sequencing (NGS) plays a role in neuro-oncology research and in clinical diagnosis and management. Here, we describe how NGS for pediatric CNS tumors impacted clinical diagnosis and therapy at a single… read more here.

Keywords: therapy; diagnosis management; pediatric cns; cns tumors ... See more keywords
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MRI Patterns in Pediatric CNS Hemophagocytic Lymphohistiocytosis

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Published in 2021 at "American Journal of Neuroradiology"

DOI: 10.3174/ajnr.a7292

Abstract: Distinct MR imaging patterns correlating with clinical phenotypes and possible genetic underpinnings were recognized in this cohort of pediatric patients with CNS hemophagocytic lymphohistiocytosis. Disruptive mutations and missense mutations with absent protein expression correlate with… read more here.

Keywords: hemophagocytic lymphohistiocytosis; imaging patterns; cns hemophagocytic; lymphohistiocytosis ... See more keywords
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The Road to CAR T-Cell Therapies for Pediatric CNS Tumors: Obstacles and New Avenues

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Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.815726

Abstract: Pediatric central nervous system (CNS) tumors are the most common solid tumors diagnosed in children and are the leading cause of pediatric cancer-related death. Those who do survive are faced with the long-term adverse effects… read more here.

Keywords: pediatric cns; car; car cell; cns tumors ... See more keywords