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   Articles with "pediatric diffuse" as a keyword



DIPG-45. TARGETING HYPERACETYLATION IN PEDIATRIC DIFFUSE MIDLINE GLIOMAS USING ONCOLYTIC ADENOVIRUSES

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae064.098

Abstract: Abstract BACKGROUND H3K27-altered pediatric diffuse midline glioma (DMG) is a highly aggressive type of brain tumor with a 5-year survival rate of less than 2%. Conventional treatments are restricted to palliative radiation therapy. Therefore, effective… read more here.

Keywords: delta rgd; dmg; pediatric diffuse; oncolytic adenoviruses ... See more keywords

TMET-39. DUAL TARGETING OF MAP KINASE SIGNALING AND METABOLISM IS A THERAPEUTIC VULNERABILITY IN PEDIATRIC DIFFUSE MIDLINE GLIOMAS

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae165.1177

Abstract: Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results in aberrantly permissive activation of oncogenic signaling pathways. Previous studies of diffuse midline… read more here.

Keywords: pediatric diffuse; diffuse midline; dmg h3k27a; kinase ... See more keywords

Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy

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recommendations! Published in 2018 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-18-1345

Abstract: Purpose: Pediatric diffuse midline glioma (DMG) are highly malignant tumors with poor clinical outcomes. Over 70% of patients with DMG harbor the histone 3 p.K27M (H3K27M) mutation, which correlates with a poorer clinical outcome, and… read more here.

Keywords: liquid biopsy; pediatric diffuse; diffuse midline; tumor ... See more keywords

Pediatric Diffuse Midline Gliomas: An Unfinished Puzzle

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recommendations! Published in 2022 at "Diagnostics"

DOI: 10.3390/diagnostics12092064

Abstract: Diffuse midline glioma (DMG) is a heterogeneous group of aggressive pediatric brain tumors with a fatal prognosis. The biological hallmark in the major part of the cases is H3K27 alteration. Prognosis remains poor, with median… read more here.

Keywords: diffuse midline; midline gliomas; tumor; pediatric diffuse ... See more keywords

BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas

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recommendations! Published in 2024 at "eLife"

DOI: 10.7554/elife.91313

Abstract: Pediatric diffuse midline gliomas (pDMG) are an aggressive type of childhood cancer with a fatal outcome. Their major epigenetic determinism has become clear, notably with the identification of K27M mutations in histone H3. However, the… read more here.

Keywords: diffuse midline; pediatric diffuse; midline gliomas; bmp2 bmp7 ... See more keywords