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Published in 2021 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2021.2011905
Abstract: We consider the case of pediatric dose-finding trials with extremely limited sample size. The operating characteristics of the standard design, the Continual Reassessment Method (CRM), are only well described for sample sizes of about 20…
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Keywords:
pediatric dose;
trial;
trial adults;
feasibility pediatric ... See more keywords
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Published in 2022 at "Radiation protection dosimetry"
DOI: 10.1093/rpd/ncac163
Abstract: Clinical challenges in pediatrics dose estimation by the displayed computed tomography (CT) dose indices may lead to inaccuracy, and thus size-specific dose estimate (SSDE) is introduced for better-personalized dose estimation. This study aims to estimate…
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Keywords:
specific size;
pediatric dose;
ssde;
estimation pediatric ... See more keywords
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Published in 2017 at "Radiology"
DOI: 10.1148/radiol.2017161530
Abstract: Purpose To determine diagnostic reference ranges on the basis of the size of a pediatric patient's chest and to develop a method to estimate computed tomographic (CT) scanner-specific mean size-specific dose estimates (SSDEs) as a…
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Keywords:
reference ranges;
basis;
pediatric dose;
reference ... See more keywords
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Published in 2020 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-020-00429-y
Abstract: Background This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric doses and ignores the age-related physiological…
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Keywords:
adult;
based pharmacokinetic;
prediction lisinopril;
pediatric dose ... See more keywords