On the feasibility of pediatric dose-finding trials in small samples with information from a preceding trial in adults.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2021.2011905
Abstract: We consider the case of pediatric dose-finding trials with extremely limited sample size. The operating characteristics of the standard design, the Continual Reassessment Method (CRM), are only well described for sample sizes of about 20… read more here.
Keywords: pediatric dose; trial; trial adults; feasibility pediatric ... See more keywords
Estimation of Pediatric Dose Descriptors Adapted to Individual Specific Size From CT Examinations.
Sign Up to like & getrecommendations! Published in 2022 at "Radiation protection dosimetry"
DOI: 10.1093/rpd/ncac163
Abstract: Clinical challenges in pediatrics dose estimation by the displayed computed tomography (CT) dose indices may lead to inaccuracy, and thus size-specific dose estimate (SSDE) is introduced for better-personalized dose estimation. This study aims to estimate… read more here.
Keywords: specific size; pediatric dose; ssde; estimation pediatric ... See more keywords
Pediatric Chest CT Diagnostic Reference Ranges: Development and Application.
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DOI: 10.1148/radiol.2017161530
Abstract: Purpose To determine diagnostic reference ranges on the basis of the size of a pediatric patient's chest and to develop a method to estimate computed tomographic (CT) scanner-specific mean size-specific dose estimates (SSDEs) as a… read more here.
Keywords: reference ranges; basis; pediatric dose; reference ... See more keywords
Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model
Sign Up to like & getrecommendations! Published in 2020 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-020-00429-y
Abstract: Background This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric doses and ignores the age-related physiological… read more here.
Keywords: adult; based pharmacokinetic; prediction lisinopril; pediatric dose ... See more keywords