Abstract 3042: Generation, characterization and functional validation of novel preclinical models for human pediatric glioma
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DOI: 10.1158/1538-7445.am2021-3042
Abstract: Tumors of the central nervous system are the most common form of childhood malignancy, and remain the leading cause of cancer-related morbidity and mortality in children. Despite extensive efforts, the efficacy of the traditional treatments… read more here.
Keywords: biology; validation; pediatric glioma; tumor ... See more keywords
Histone H3.3K27M Mobilizes Multiple Cancer/Testis (CT) Antigens in Pediatric Glioma
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DOI: 10.1158/1541-7786.mcr-17-0460
Abstract: Lysine to methionine mutations at position 27 (K27M) in the histone H3 (H3.3 and H3.1) are highly prevalent in pediatric high-grade gliomas (HGG) that arise in the midline of the central nervous system. H3K27M perturbs… read more here.
Keywords: pediatric glioma; glioma; hla; pediatric hgg ... See more keywords
Glioma‐induced peritumoral hyperexcitability in a pediatric glioma model
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DOI: 10.14814/phy2.14567
Abstract: Epileptic seizures are among the most common presenting symptom in patients with glioma. The etiology of glioma‐related seizures is complex and not completely understood. Studies using adult glioma patient tissue and adult glioma mouse models,… read more here.
Keywords: pediatric glioma; peritumoral neurons; glioma; adult glioma ... See more keywords
Association of LINC00673 rs11655237 polymorphism with pediatric glioma susceptibility in a Chinese population.
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DOI: 10.21037/tp-21-291
Abstract: Background Previous researches have suggested that LINC00673 rs11655237 C>T polymorphism might be correlated to cancer susceptibility. However, its correlation with pediatric glioma is unknown. Therefore, this study aimed to determine whether LINC00673 rs11655237 C>T polymorphism… read more here.
Keywords: rs11655237 polymorphism; pediatric glioma; linc00673 rs11655237; susceptibility ... See more keywords