Pediatric high-grade glioma: current molecular landscape and therapeutic approaches
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2393-0
Abstract: High-grade pediatric central nervous system glial tumors are comprised primarily of anaplastic astrocytomas (AA, WHO grade III) and glioblastomas (GBM, WHO grade IV). High-grade gliomas are most commonly diagnosed in the primary setting in children,… read more here.
Keywords: pediatric high; high grade; grade glioma; grade ... See more keywords
EXTH-48. BMP4 BINDING PEPTIDE AMPHIPHILE NANOFIBERS FOR THE TREATMENT OF PEDIATRIC HIGH-GRADE GLIOMAS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.402
Abstract: Pediatric high-grade glioma (pHGG) is among the most formidable cancers occurring in childhood. Bone morphogenetic protein 4 (BMP4) reduces the number of glioma stem-like cells and induces apoptosis. Treating tumors with exogenous BMP4 could prove… read more here.
Keywords: pediatric high; gliomas; high grade; peptide amphiphile ... See more keywords
HGG-36. HIF-2: A NEW DRUG TARGET IN PEDIATRIC HIGH-GRADE GLIOMA WITH PROMISING PRECLINICAL RESULTS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.317
Abstract: Abstract Pediatric high-grade gliomas (pHGGs) have a very dismal prognosis and need new innovative strategy for treatment. Despite the past discovery of histone H3 driver mutations, we are not able for instance to stop this… read more here.
Keywords: pediatric high; high grade; drug; hif 2alpha ... See more keywords
HGG-21. MALIGNANT SYNAPTIC PLASTICITY IN PEDIATRIC HIGH-GRADE GLIOMAS
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noab090.085
Abstract: Abstract Pediatric high-grade gliomas (pHGG) are a devastating group of diseases that urgently require novel therapeutic options. We have previously demonstrated that pHGGs directly synapse onto neurons and the subsequent tumor cell depolarization, mediated by… read more here.
Keywords: pediatric high; glioma; high grade; bdnf ... See more keywords
PDTM-11. GAINING INSIGHTS INTO THE INFLAMMATORY MICROENVIRONMENT OF PEDIATRIC HIGH-GRADE GLIOMAS USING GEMMs AND PATIENT SAMPLES
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.787
Abstract: Pediatric high-grade gliomas (pHGG) account for the most cancer-related deaths in children, as there are no effective therapies available. It is known tumor associated macrophages (TAM) can make up 30–40% of the total tumor cell… read more here.
Keywords: grade gliomas; pediatric high; rcas; high grade ... See more keywords
Epigenomic landscape and 3D genome structure in pediatric high-grade glioma
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abg4126
Abstract: Distinct genomic structural variations are found in pediatric high-grade glioma, affecting tumor gene expression. Pediatric high-grade gliomas (pHGGs), including glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG), are morbid brain tumors. Even with treatment… read more here.
Keywords: structure; pediatric high; grade glioma; high grade ... See more keywords
Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16500
Abstract: Pediatric high grade glioma (pHGGs), including sus-tentorial and diffuse intrinsic pontine gliomas, are known to have a very dismal prognosis. For instance, even an increased knowledge on molecular biology driving this brain tumor entity, there… read more here.
Keywords: pediatric high; hif; gliomas; high grade ... See more keywords
Pediatric High Grade Gliomas in the Context of Cancer Predisposition Syndromes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Korean Neurosurgical Society"
DOI: 10.3340/jkns.2018.0031
Abstract: Germline mutations in cancer causing genes result in high risk of developing cancer throughout life. These cancer predisposition syndromes (CPS) are especially prevalent in childhood brain tumors and impact both the patient’s and other family… read more here.
Keywords: pediatric high; high grade; cancer predisposition; grade gliomas ... See more keywords
Epigenetic programming of pediatric high-grade glioma: Pushing beyond proof of concept to clinical benefit
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1089898
Abstract: Pediatric high-grade gliomas (pHGG) are a molecularly diverse group of malignancies, each incredibly aggressive and in dire need of treatment advancements. Genomic analysis has revolutionized our understanding of these tumors, identifying biologically relevant subgroups with… read more here.
Keywords: high grade; grade gliomas; pediatric high; epigenetic programming ... See more keywords
Chromatin mutations in pediatric high grade gliomas
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1104129
Abstract: Pediatric high grade gliomas (HGG) are lethal tumors which are currently untreatable. A number of recent studies have provided much needed insights into the mutations and mechanisms which drive oncogenesis in pediatric HGGs. It is… read more here.
Keywords: high grade; grade gliomas; pediatric high; chromatin mutations ... See more keywords
Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2020.561487
Abstract: Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition,… read more here.
Keywords: pediatric high; high grade; cancer predisposition; grade gliomas ... See more keywords