Evaluating the safety of perioperative dexamethasone treatment: A retrospective analysis of a single center pediatric low‐grade glioma cohort
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DOI: 10.1002/ijc.34399
Abstract: In addition to surgical management, corticosteroids have proven to be beneficial in the management of acute symptoms related to CNS tumors, and have been widely used for many decades, with dexamethasone (DM) representing the most… read more here.
Keywords: safety; pfs; glioma; treatment ... See more keywords
Molecular markers and targeted therapy in pediatric low-grade glioma
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DOI: 10.1007/s11060-020-03529-1
Abstract: Recently discovered molecular alterations in pediatric low-grade glioma have helped to refine the classification of these tumors and offered novel targets for therapy. Genetic aberrations may combine with histopathology to offer new insights into glioma… read more here.
Keywords: therapy; low grade; pediatric low; grade glioma ... See more keywords
MicroRNA (miR) 125b regulates cell growth and invasion in pediatric low grade glioma
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DOI: 10.1038/s41598-018-30942-4
Abstract: Members of the miR-125 family are strongly expressed in several tissues, particularly brain, but may be dysregulated in cancer including adult and pediatric glioma. In this study, miR-125 members were downregulated in pilocytic astrocytoma (PA)… read more here.
Keywords: glioma; mir 125; grade; mir 125b ... See more keywords
Doubling Recruitment of Pediatric Low-grade Glioma within Two Decades does not change Outcome - Report from the German LGG Studies.
Sign Up to like & getrecommendations! Published in 2021 at "Klinische Padiatrie"
DOI: 10.1055/a-1471-5897
Abstract: BACKGROUND Successive multicenter studies for pediatric low-grade glioma (LGG) in Germany were accompanied by a doubling of annual recruitment over 2 decades. We investigated whether this increase conveyed a change of epidemiologic characteristics or survival.… read more here.
Keywords: lgg; grade glioma; der; pediatric low ... See more keywords
Clinical impact of combined epigenetic and molecular analysis of pediatric low grade gliomas.
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DOI: 10.1093/neuonc/noaa077
Abstract: BACKGROUND Both genetic and methylation analysis have been shown to provide insight into the diagnosis and prognosis of many brain tumors. However, the implication of methylation profiling and its interaction with genetic alterations in pediatric… read more here.
Keywords: methylation; analysis; pediatric low; grade gliomas ... See more keywords
LGG-44. PROGNOSTIC SIGNIFICANCE OF IMAGING CHARACTERISTICS IN PEDIATRIC LOW GRADE GLIOMAS
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DOI: 10.1093/neuonc/noaa222.422
Abstract: Abstract Pediatric low-grade gliomas (pLGG) account for one third of all central nervous system (CNS) tumors. MRI is the preferred imaging modality for diagnosis and response evaluation. This study aims to evaluate if radiographic characteristics… read more here.
Keywords: diagnosis; imaging characteristics; pediatric low; grade gliomas ... See more keywords
LGG-51. BRAF ALTERATIONS IN PEDIATRIC LOW-GRADE GLIOMAS: RESULTS FROM A BRAZILIAN COHORT
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DOI: 10.1093/neuonc/noaa222.429
Abstract: Abstract BACKGROUND Pediatric low grade gliomas (PLGG) are the most common central nervous system neoplasms in children. These are driven almost exclusively by alterations in the RAS/MAPK pathway. Specifically, alterations in the BRAF gene have… read more here.
Keywords: braf alterations; brazilian cohort; braf; pediatric low ... See more keywords
RONC-12. TREATMENT AGE AND NEUROCOGNITIVE OUTCOMES FOLLOWING PROTON BEAM RADIOTHERAPY FOR PEDIATRIC LOW GRADE GLIOMA
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DOI: 10.1093/neuonc/noaa222.782
Abstract: Abstract INTRODUCTION Younger age at radiotherapy increases cognitive risk for patients with pediatric low grade glioma (LGG). We examined the impact of age at treatment on cognitive trajectories in LGG patients treated with proton radiotherapy… read more here.
Keywords: age; treatment; radiotherapy; pediatric low ... See more keywords
LGG-32. Integrated biologic, radiologic and clinical analysis of pediatric low-grade gliomas during and after targeted therapy treatment
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DOI: 10.1093/neuonc/noac079.344
Abstract: Abstract BACKGROUND: Pediatric low grade gliomas (pLGGs) are the most common central nervous system tumor in children, characterized by driver alterations in the RAS and MAPK pathways. Genomic advances have facilitated use of molecular targeted… read more here.
Keywords: therapy; targeted therapy; analysis; treatment ... See more keywords
The first-in-class ERK inhibitor ulixertinib shows promising activity in MAPK-driven pediatric low-grade glioma models.
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DOI: 10.1093/neuonc/noac183
Abstract: BACKGROUND Pediatric low-grade gliomas (pLGG) are the most common pediatric central nervous system tumors, with driving alterations typically occurring in the MAPK pathway. The ERK1/2 inhibitor ulixertinib (BVD-523) has shown promising responses in adult patients… read more here.
Keywords: ulixertinib; inhibitor ulixertinib; activity; mapk driven ... See more keywords
A nationwide evaluation of bevacizumab-based treatments in pediatric low-grade glioma in the UK: Safety, efficacy, visual morbidity, and outcomes
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DOI: 10.1093/neuonc/noac223
Abstract: Abstract Background Bevacizumab is increasingly used in children with pediatric low-grade glioma (PLGG) despite limited evidence. A nationwide UK service evaluation was conducted to provide larger cohort “real life” safety and efficacy data including functional… read more here.
Keywords: grade glioma; safety efficacy; bevacizumab; glioma ... See more keywords