DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-019-00830-4
Abstract: The brainstem-based pedunculopontine nucleus (PPN) traditionally associates with motor function, but undergoes extensive degeneration during Parkinson’s disease (PD), which correlates with axial motor deficits. PPN-deep brain stimulation (DBS) can alleviate certain symptoms, but its mechanism(s)… read more here.
Keywords: ppn; cholinergic neurons; dopamine; striatal dopamine ... See more keywords
Pedunculopontine-induced cortical decoupling as the neurophysiological locus of dissociation.
Sign Up to like & getrecommendations! Published in 2022 at "Psychological review"
DOI: 10.1037/rev0000353
Abstract: Mounting evidence suggests an association between aberrant sleep phenomena and dissociative experiences. However, no wake-sleep boundary theory provides a compelling explanation of dissociation or specifies its physiological substrates. We present a theoretical account of dissociation… read more here.
Keywords: cortical decoupling; dissociation; pedunculopontine induced; rem sleep ... See more keywords