Direct localization and delineation of human pedunculopontine nucleus based on a self‐supervised magnetic resonance image super‐resolution method
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26311
Abstract: The pedunculopontine nucleus (PPN) is a small brainstem structure and has attracted attention as a potentially effective deep brain stimulation (DBS) target for the treatment of Parkinson's disease (PD). However, the in vivo location of… read more here.
Keywords: magnetic resonance; brain; resolution; image ... See more keywords
Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27540
Abstract: In summary, what we have learned about the PPN and MLR over the past few years undermines the simplistic model that underpins the rationale for PPN DBS. Our understanding of the relevant circuitry remains rudimentary.… read more here.
Keywords: pedunculopontine nucleus; ppn dbs; time; nucleus parkinson ... See more keywords
Reciprocal interaction between monoaminergic systems and the pedunculopontine nucleus: Implication in the mechanism of L-DOPA
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.08.014
Abstract: The pedunculopontine nucleus (PPN) is part of the mesencephalic locomotor region (MLR) and has been involved in the control of gait, posture, locomotion, sleep, and arousal. It likely participates in some motor and non-motor symptoms… read more here.
Keywords: pedunculopontine nucleus; monoaminergic systems; reciprocal interaction; mechanism ... See more keywords
Non-motor connections of the pedunculopontine nucleus of the rat and human brain
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience letters"
DOI: 10.1016/j.neulet.2021.136308
Abstract: INTRODUCTION The connections of the pedunculopontine nucleus (PPN) with motor areas of the central nervous system (CNS) are well described in the literature, in contrast relations with non-motor areas are lacking. Thus, the aim of… read more here.
Keywords: ppn; pedunculopontine nucleus; non motor; motor ... See more keywords
Free-water imaging of the cholinergic basal forebrain and pedunculopontine nucleus in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac127
Abstract: Abstract Free-water imaging can predict and monitor dopamine system degeneration in people with Parkinson’s disease. It can also enhance the sensitivity of traditional diffusion tensor imaging (DTI) metrics for indexing neurodegeneration. However, these tools are… read more here.
Keywords: free water; water; parkinson disease; cholinergic basal ... See more keywords
Safety and feasibility of curved lead simultaneously implanted into pedunculopontine nucleus and subthalamic nucleus
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002398
Abstract: To the Editor: Combined nuclei stimulation may have a synergistic effect on controlling the symptoms of nervous system diseases and improving quality of life. [1] However, increasing of leads may increase costs and complications. [2]… read more here.
Keywords: subthalamic nucleus; lead simultaneously; curved lead; safety feasibility ... See more keywords
Pedunculopontine Nucleus Dysconnectivity Correlates With Gait Impairment in Parkinson’s Disease: An Exploratory Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.874692
Abstract: Background Gait impairment is a debilitating and progressive feature of Parkinson’s disease (PD). Increasing evidence suggests that gait control is partly mediated by cholinergic signaling from the pedunculopontine nucleus (PPN). Objective We investigated whether PPN… read more here.
Keywords: connectivity; parkinson disease; structural connectivity; gait impairment ... See more keywords
Dystonia and the pedunculopontine nucleus: Current evidences and potential mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1065163
Abstract: Being a major component of the midbrain locomotion region, the pedunculopontine nucleus (PPN) is known to have various connections with the basal ganglia, the cerebral cortex, thalamus, and motor regions of the brainstem and spinal… read more here.
Keywords: dystonia pedunculopontine; motor; potential mechanisms; dystonia ... See more keywords