Tumor suppressor p53 inhibits porcine epidemic diarrhea virus infection via interferon-mediated antiviral immunity
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2019.02.005
Abstract: HIGHLIGHTSp53 exhibits clear antiviral role in PEDV infection.Enhanced PEDV replication in p53‐knockout cells is related to attenuated IFN pathway.Enhance p53 expression provides a new strategy to control PEDV infections. ABSTRACT p53 is a tumor suppressor… read more here.
Keywords: pedv infection; porcine epidemic; tumor suppressor; epidemic diarrhea ... See more keywords
Porcine epidemic diarrhoea virus (PEDV) infection activates AMPK and JNK through TAK1 to induce autophagy and enhance virus replication
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2127192
Abstract: ABSTRACT Autophagy plays an important role in defending against invading microbes. However, numerous viruses can subvert autophagy to benefit their replication. Porcine epidemic diarrhoea virus (PEDV) is an aetiological agent that causes severe porcine epidemic… read more here.
Keywords: pedv infection; tak1; replication; virus ... See more keywords
Tight Junction Protein Occludin Is a Porcine Epidemic Diarrhea Virus Entry Factor
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00202-17
Abstract: ABSTRACT Porcine epidemic diarrhea virus (PEDV), the causative agent of porcine epidemic diarrhea, has caused huge economic losses in pig-producing countries. Although PEDV was long believed to replicate in the intestinal epithelium by using aminopeptidase… read more here.
Keywords: pedv infection; infection; occludin; virus entry ... See more keywords
LncRNA446 Regulates Tight Junctions by Inhibiting the Ubiquitinated Degradation of Alix after Porcine Epidemic Diarrhea Virus Infection
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.01884-22
Abstract: Porcine epidemic diarrhea is an acute, highly contagious enteric viral disease severely affecting the pig industry, for which current vaccines are inefficient due to the high variability of PEDV. Because PEDV infection can lead to… read more here.
Keywords: infection; pedv infection; porcine epidemic; epidemic diarrhea ... See more keywords
Chestnut inner shell extract inhibits viral entry of porcine epidemic diarrhea virus and other coronaviruses in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.930608
Abstract: Porcine epidemic diarrhea virus (PEDV) is a coronavirus that causes acute diarrhea in suckling piglets. Although vaccines are able to reduce the incidence of PEDV infection, outbreaks of PEDV continue to be reported worldwide and… read more here.
Keywords: entry; pedv infection; diarrhea; porcine epidemic ... See more keywords
m6A Demethylase ALKBH5 Restrains PEDV Infection by Regulating GAS6 Expression in Porcine Alveolar Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116191
Abstract: Porcine epidemic diarrhea virus (PEDV) is a burdensome coronavirus for the global pig industry. Although its fecal-oral route has been well-recognized, increasing evidence suggests that PEDV can also spread through airborne routes, indicating that the… read more here.
Keywords: infection; alkbh5; pedv infection; demethylase alkbh5 ... See more keywords
PEDV Infection Generates Conformation-Specific Antibodies That Can Be Effectively Detected by a Cell-Based ELISA
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13020303
Abstract: Porcine epidemic diarrhea virus (PEDV) is a coronavirus that causes serious and highly contagious enteric disease in swine worldwide. In this study, we constructed a recombinant baculovirus (S-Bac) expressing full-length spike protein of the virulent… read more here.
Keywords: pedv infection; based elisa; cell based; specific antibodies ... See more keywords
Ergosterol Peroxide Inhibits Porcine Epidemic Diarrhea Virus Infection in Vero Cells by Suppressing ROS Generation and p53 Activation
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14020402
Abstract: Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus that causes severe watery diarrhea in piglets with high morbidity and mortality, resulting in serious economic losses to the farming industry. Ergosterol peroxide (EP) is a sterol… read more here.
Keywords: p53 activation; pedv induced; infection; pedv infection ... See more keywords